Drug General Information
Drug ID	D0FR4S
Former ID	DNC013056
Drug Name	4-(2-aminoethyl)-1,2,5-oxadiazol-3-ol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528295]
Structure		Download 2D MOL 3D MOL
Formula	C4H7N3O2
Canonical SMILES	C(CN)C1=NONC1=O
InChI	1S/C4H7N3O2/c5-2-1-3-4(8)7-9-6-3/h1-2,5H2,(H,7,8)
InChIKey	LGTWAFYEFVSZIU-UHFFFAOYSA-N
PubChem Compound ID	11607975
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[528295]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[528295]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[528295]
	Gamma-aminobutyric acid receptor subunit beta-2	Target Info	Inhibitor	[528295]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Serotonergic synapse
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 528295	J Med Chem. 2006 Jul 13;49(14):4442-6.Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds.
Ref 528295	J Med Chem. 2006 Jul 13;49(14):4442-6.Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.