Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0FY6Q
|
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| Former ID |
DIB009987
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| Drug Name |
JTK-109
|
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| Drug Type |
Small molecular drug
|
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| Indication | HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10:B17.1, B18.2] | Discontinued in Phase 1 | [1] | ||
| Company |
Japan Tobacco Inc
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C27H26N2O3
|
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| Canonical SMILES |
C1CC(=O)N(C1)c1ccc(c(c1)COc1cc(c(c2n(C3CCCCC3)c3c(n2)cc<br />(C(=O)O)cc3)cc1)F)c1ccc(cc1)Cl
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Hepatitis C virus NS5B polymerase | Target Info | Inhibitor | [2] | |
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018157) | ||||
| REF 2 | Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109. J Med Chem. 2006 Jul 27;49(15):4721-36. | ||||
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