Drug Information

Drug General Information
Drug ID
D0G0GI
Former ID
DNC003911
Drug Name
DMP-696
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Terminated [540437], [546984]
Structure
Download
2D MOL

3D MOL
Formula
C18H21Cl2N5O2
InChI
InChI=1S/C18H21Cl2N5O2/c1-10-16(14-6-5-12(19)7-15(14)20)17-21-11(2)22-18(25(17)24-10)23-13(8-26-3)9-27-4/h5-7,13H,8-9H2,1-4H3,(H,21,22,23)
InChIKey
MDWRPTOUDPFXKK-UHFFFAOYSA-N
PubChem Compound ID
9909468
PubChem Substance ID
14879673, 24190230, 45981129, 47359931, 48404513, 74628179, 103225609, 103984403, 128581667, 134341116, 178100486, 228994731
Target and Pathway
Target(s) Corticotropin releasing factor receptor 1 Target Info Inhibitor [530226]
KEGG Pathway Neuroactive ligand-receptor interaction
Long-term depression
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Cortocotropin releasing factor receptor signaling pathway
Reactome Class B/2 (Secretin family receptors)
G alpha (s) signalling events
WikiPathways GPCRs, Class B Secretin-like
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
GPCR ligand binding
GPCR downstream signaling
References
Ref 540437(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3499).
Ref 546984Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011782)
Ref 530226J Med Chem. 2009 Jul 23;52(14):4161-72.In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.