Drug Information

Drug General Information
Drug ID
D0G0UZ
Former ID
DIB001587
Drug Name
SBP-002
Synonyms
Coramsine; Solasonine + solamargine; Solasodine glycosides (cancer, injectable formulation), Solbec; Solasodine glycosides (psoriasis, cream formulation), Solbec; Solasonine + solamargine (cancer), Solbec; Solasonine + solamargine (psoriasis), Solbec; SBP-002 (intravenous, cancer), Solbec; SBP-002 (psoriasis, cream formulation), Solbec
Indication Melanoma [ICD9: 172; ICD10:C43] Terminated [548186]
Company
Curacel International Pty Ltd; Freedom Eye Ltd
Structure
Download
2D MOL

3D MOL
Canonical SMILES
[C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O[C@H]1[C<br />@@H](O)[C@H](O[C@@H](O[C@H]2CC[C@]3(C(=CC[C@@H]4[C@@H]3<br />CC[C@]3([C@H]4C[C@H]4[C@@H]3[C@@H]([C@@]3(CC[C@H](CN3)C<br />)O4)C)C)C2)C)[C@@H]1O[C@@H]1O[C@H]([C@@H]([C@H]([C@H]1O<br />)O)O)C)CO.[C@@H]1([C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O<br />)O[C@@H]1[C@H](O[C@@H](O[C@H]2CC[C@]3(C(=CC[C@@H]4[C@@H<br />]3CC[C@]3([C@H]4C[C@H]4[C@@H]3[C@@H]([C@@]3(CC[C@H](CN3<br />)C)O4)C)C)C2)C)[C@@H]([C@H]1O)O[C@@H]1O[C@H]([C@@H]([C@<br />H]([C@H]1O)O)O)C)CO
Target and Pathway
Target(s) Interleukin-6 receptor Target Info Modulator [556264]
KEGG Pathway Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Non-alcoholic fatty liver disease (NAFLD)
Reactome MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
WikiPathways SIDS Susceptibility Pathways
Senescence and Autophagy in Cancer
IL-6 signaling pathway
Differentiation Pathway
Interleukin-6 signaling
References
Ref 548186Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022850)
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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