Drug Information

Drug General Information
Drug ID
D0G1JJ
Former ID
DNC009701
Drug Name
(S)-3-(1'-Adamantanecarbonyl)amino-caprolactam
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530113]
Structure
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2D MOL

3D MOL
Formula
C17H26N2O2
Canonical SMILES
C1CCNC(=O)C(C1)NC(=O)C23CC4CC(C2)CC(C4)C3
InChI
1S/C17H26N2O2/c20-15-14(3-1-2-4-18-15)19-16(21)17-8-11-5-12(9-17)7-13(6-11)10-17/h11-14H,1-10H2,(H,18,20)(H,19,21)/t11?,12?,13?,14-,17?/m0/s1
InChIKey
FRJOFURBYVCNEN-ZZTKBFGJSA-N
PubChem Compound ID
11659300
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Inhibitor [530113]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 530113J Med Chem. 2009 Jun 11;52(11):3591-5.Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors.
Ref 530113J Med Chem. 2009 Jun 11;52(11):3591-5.Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors.

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