Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0G1RH
|
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| Former ID |
DIB010796
|
||||
| Drug Name |
NPS-2143
|
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| Drug Type |
Small molecular drug
|
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| Company |
NPS Pharmaceuticals
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C24H25ClN2O2
|
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| InChI |
InChI=1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1
|
||||
| InChIKey |
PZUJQWHTIRWCID-HXUWFJFHSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
12015260, 14855237, 17194894, 43529816, 49888603, 50232180, 57371933, 103443095, 104047510, 114787986, 121280058, 124360780, 125164693, 126646528, 126671455, 134342083, 135650739, 136340370, 136349529, 136367660, 136367790, 142774442, 152258052, 152343807, 160646890, 162011657, 162038035, 162202765, 164023450, 174006304, 184823472, 198959006, 223369937, 223395496, 223666833, 238590854, 242589476, 246492847, 252220157
|
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| Target and Pathway | |||||
| Target(s) | Extracellular calcium-sensing receptor | Target Info | Antagonist | [532330] | |
| Pathway Interaction Database | E-cadherin signaling in keratinocytes | ||||
| References | |||||
| Ref 542168 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 716). | ||||
| Ref 546895 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010915) | ||||
| Ref 532330 | Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Abeta42 prompted by exogenous fibrillary or soluble Abeta25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease. Biochim Biophys Acta. 2013 Oct;1832(10):1634-52. | ||||
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