Drug Information
Drug General Information | |||||
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Drug ID |
D0G4DE
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Former ID |
DNC000313
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Drug Name |
BIA 3-202
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Drug Type |
Small molecular drug
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Indication | Parkinson's disease [ICD9: 332; ICD10:G20] | Phase 2 | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C14H11NO5
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Canonical SMILES |
C1=CC=C(C=C1)CC(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-]
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InChI |
1S/C14H11NO5/c16-12(6-9-4-2-1-3-5-9)10-7-11(15(19)20)14(18)13(17)8-10/h1-5,7-8,17-18H,6H2
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InChIKey |
MRFOLGFFTUGAEB-UHFFFAOYSA-N
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CAS Number |
CAS 274925-86-9
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Catechol-O-methyl-transferase | Target Info | Inhibitor | [2] | |
BioCyc Pathway | L-dopa degradation | ||||
Dopamine degradation | |||||
Noradrenaline and adrenaline degradation | |||||
KEGG Pathway | Steroid hormone biosynthesis | ||||
Tyrosine metabolism | |||||
Metabolic pathways | |||||
Dopaminergic synapse | |||||
PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
Dopamine receptor mediated signaling pathway | |||||
PathWhiz Pathway | Tyrosine Metabolism | ||||
WikiPathways | Methylation Pathways | ||||
Metapathway biotransformation | |||||
Estrogen metabolism | |||||
Biogenic Amine Synthesis | |||||
Dopamine metabolism | |||||
Phase II conjugation | |||||
Neurotransmitter Clearance In The Synaptic Cleft | |||||
References | |||||
REF 1 | Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease. Clin Neuropharmacol. 2008 Jan-Feb;31(1):2-18. | ||||
REF 2 | Chemical synthesis and characterization of conjugates of a novel catechol-O-methyltransferase inhibitor. Bioconjug Chem. 2002 Sep-Oct;13(5):1112-8. | ||||
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