Drug Information

Drug General Information
Drug ID
D0G4VV
Former ID
DNC005851
Drug Name
SCH-356036
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530597]
Structure
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2D MOL

3D MOL
Formula
C21H19ClFNO6S3
Canonical SMILES
CC(C1=CC=C(C=C1)S(=O)(=O)C2=C(C=C(C=C2)Cl)S(=O)(=O)C3=C<br />C=CC=C3F)NS(=O)(=O)C
InChI
1S/C21H19ClFNO6S3/c1-14(24-31(2,25)26)15-7-10-17(11-8-15)32(27,28)20-12-9-16(22)13-21(20)33(29,30)19-6-4-3-5-18(19)23/h3-14,24H,1-2H3/t14-/m0/s1
InChIKey
BQYPKXDCTROOHB-AWEZNQCLSA-N
PubChem Compound ID
9893254
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [530597]
Cannabinoid receptor 1 Target Info Inhibitor [530597]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 530597Bioorg Med Chem Lett. 2010 Feb 1;20(3):1084-9. Epub 2009 Dec 11.Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies.
Ref 530597Bioorg Med Chem Lett. 2010 Feb 1;20(3):1084-9. Epub 2009 Dec 11.Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies.

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