Drug General Information
Drug ID
D0G5GV
Former ID
DIB018135
Drug Name
[123I]iodoproxyfan
Synonyms
[125I]-iodoproxyfan
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538779]
Structure
Download
2D MOL
Formula
C13H15IN2O
InChI
InChI=1S/C13H15IN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)/i14-4
InChIKey
DCQNAFOCXVCDLB-CKVWVWRJSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Histamine H3 receptor Target Info Antagonist [525918]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538779(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1264).
Ref 525918Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131(7):1247-50.

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