Drug Information

Drug General Information
Drug ID
D0G5YR
Former ID
DIB006983
Drug Name
SAR-566658
Synonyms
CA6-targeted DM4 immunotoxin (cancer), sanofi-aventis; DM4-conjugated DS6 MAb (cancer), sanofi-aventis; DM4-conjugated anti-Muc1 monoclonal antibody (cancer), sanofi-aventis
Drug Type
Antibody
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [523101]
Company
ImmunoGen Inc
Structure
Download
2D MOL

3D MOL
Canonical SMILES
C(=O)(N*)CCCSSC(C)(C)CCC(=O)N([C@H](C(=O)O[C@@H]1[C@]2(<br />[C@@H](O2)[C@@H]([C@@H]2C[C@@](NC(=O)O2)([C@@H](/C=C/C=<br />C(/Cc2cc(N(C(=O)C1)C)c(c(c2)OC)Cl)\C)OC)O)C)C)C)C
Target and Pathway
Target(s) Mucin 1 Target Info [549969]
WikiPathways Hematopoietic Stem Cell Differentiation
References
Ref 523101ClinicalTrials.gov (NCT01156870) First in Man Study of SAR566658 Administered in Patients With CA6-Positive and Refractory Solid Tumor. U.S. National Institutes of Health.
Ref 549969Integrating in vitro signaling and drug response data from single cell network profiling (SCNP) to inform on individual's AML biology.Molecular Cancer Therapeutics. 11/2011; 10(Supplement 1):A73-A73.

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