Drug General Information
Drug ID
D0G6HZ
Former ID
DNC004158
Drug Name
PD-29361
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546624]
Structure
Download
2D MOL

3D MOL

Formula
C31H36N4O2
Canonical SMILES
C1CCN(CC1)CC2=CC(=C3C=CNC=C3C2=O)CC4=CC(=C(C5=C4C=CC=N5<br />)O)CN6CCCCC6
InChI
1S/C31H36N4O2/c36-30-24(20-34-12-3-1-4-13-34)17-22(26-9-11-32-19-28(26)30)16-23-18-25(21-35-14-5-2-6-15-35)31(37)29-27(23)8-7-10-33-29/h7-11,17-19,32,37H,1-6,12-16,20-21H2
InChIKey
VDZQVHXDGUXCCT-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Voltage-dependent N-type calcium channel Target Info Inhibitor [534799]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Synaptic vesicle cycle
Retrograde endocannabinoid signaling
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Taste transduction
Type II diabetes mellitus
Morphine addiction
Nicotine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Thyrotropin-releasing hormone receptor signaling pathway
Endogenous cannabinoid signaling
GABA-B receptor II signaling
Reactome Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
WikiPathways Calcium Regulation in the Cardiac Cell
Synaptic Vesicle Pathway
References
Ref 546624Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009238)
Ref 534799Bioorg Med Chem Lett. 1998 Sep 22;8(18):2415-8.Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers.

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