Drug Information

Drug General Information
Drug ID
D0G7PB
Former ID
DNC006173
Drug Name
N-methyl-N-ethyl estradiol-16-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528033]
Structure
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2D MOL

3D MOL
Formula
C22H31NO3
Canonical SMILES
CCN(C)C(=O)C1CC2C3CCC4=C(C3CCC2(C1O)C)C=CC(=C4)O
InChI
1S/C22H31NO3/c1-4-23(3)21(26)18-12-19-17-7-5-13-11-14(24)6-8-15(13)16(17)9-10-22(19,2)20(18)25/h6,8,11,16-20,24-25H,4-5,7,9-10,12H2,1-3H3/t16?,17?,18?,19?,20-,22-/m0/s1
InChIKey
UVOQIEBXUFHOKA-GFEBWMDQSA-N
PubChem Compound ID
44407332
Target and Pathway
Target(s) Estradiol 17 beta-dehydrogenase 1 Target Info Inhibitor [528033]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome The canonical retinoid cycle in rods (twilight vision)
WikiPathways Steroid Biosynthesis
Metabolism of steroid hormones and vitamin D
Prostate Cancer
References
Ref 528033J Med Chem. 2006 Feb 23;49(4):1325-45.Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Ref 528033J Med Chem. 2006 Feb 23;49(4):1325-45.Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

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