Drug General Information
Drug ID	D0G7RA
Former ID	DNC013863
Drug Name	4-(4-Chlorophenyl)-5-p-tolyl-3H-1,2-dithiol-3-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529881]
Structure		Download 2D MOL 3D MOL
Formula	C16H11ClOS2
Canonical SMILES	CC1=CC=C(C=C1)C2=C(C(=O)SS2)C3=CC=C(C=C3)Cl
InChI	1S/C16H11ClOS2/c1-10-2-4-12(5-3-10)15-14(16(18)20-19-15)11-6-8-13(17)9-7-11/h2-9H,1H3
InChIKey	NLGIFTIQVVCDPR-UHFFFAOYSA-N
PubChem Compound ID	44564004
Target and Pathway
Target(s)	Prostaglandin G/H synthase 1	Target Info	Inhibitor	[529881]
BioCyc Pathway	C20 prostanoid biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Platelet activation
	Serotonergic synapse
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Prostaglandin Synthesis and Regulation
	Arachidonic acid metabolism
	Phase 1 - Functionalization of compounds
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 529881	Bioorg Med Chem. 2009 Jan 15;17(2):558-68. Epub 2008 Dec 6.Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.
Ref 529881	Bioorg Med Chem. 2009 Jan 15;17(2):558-68. Epub 2008 Dec 6.Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.

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