Drug Information

Drug General Information
Drug ID
D0G9BX
Former ID
DNC003977
Drug Name
SC-47643
Drug Type
Small molecular drug
Indication Discovery agent Terminated [545332]
Structure
Download
2D MOL

3D MOL
Formula
C22H35N5O5
Canonical SMILES
COC1=CC=C(C=C1)CCNC(=O)C(CC(=O)O)NC(=O)CCCCCCCN=C(N)N
InChI
1S/C22H35N5O5/c1-32-17-10-8-16(9-11-17)12-14-25-21(31)18(15-20(29)30)27-19(28)7-5-3-2-4-6-13-26-22(23)24/h8-11,18H,2-7,12-15H2,1H3,(H,25,31)(H,27,28)(H,29,30)(H4,23,24,26)
InChIKey
LVVRYABDHQGPGK-UHFFFAOYSA-N
PubChem Compound ID
44353584
Target and Pathway
Target(s) Proteinase activated receptor 4 Target Info Inhibitor [533764]
mRNA of integrin beta 3 Target Info Inhibitor [533764]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Pathways in cancerhsa04015:Rap1 signaling pathway
Phagosome
PI3K-Akt signaling pathway
Osteoclast differentiation
Focal adhesion
ECM-receptor interaction
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Thyroid hormone signaling pathway
Proteoglycans in cancer
MicroRNAs in cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy
NetPath Pathway Leptin Signaling Pathway
PANTHER Pathway Blood coagulation
Pathway Interaction Database PAR4-mediated thrombin signaling eventsil4_2pathway:IL4-mediated signaling events
Integrin family cell surface interactions
Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Osteopontin-mediated events
Nectin adhesion pathway
Arf6 signaling events
S1P1 pathway
Integrins in angiogenesis
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Signaling events mediated by VEGFR1 and VEGFR2
Ephrin B reverse signaling
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)R-HSA-114608:Platelet degranulation
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
MAP2K and MAPK activation
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Thrombin signalling through proteinase activated receptors (PARs)
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
TGF beta Signaling Pathway
Osteoblast Signaling
Focal Adhesion
Hematopoietic Stem Cell Differentiation
Human Complement System
Syndecan interactions
Extracellular matrix organization
Elastic fibre formation
Primary Focal Segmental Glomerulosclerosis FSGS
Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin-mediated Cell Adhesion
L1CAM interactions
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
Cell surface interactions at the vascular wall
Serotonin Transporter Activity
Osteopontin Signaling
Osteoclast Signaling
References
Ref 545332Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002874)
Ref 533764J Med Chem. 1995 Jan 6;38(1):34-41.Novel thiazole-based heterocycles as selective inhibitors of fibrinogen-mediated platelet aggregation.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.