Drug General Information
Drug ID
Former ID
Drug Name
Indication Discovery agent Investigative [525872]


Target and Pathway
Target(s) Ribosomal protein S6 kinase Target Info Inhibitor [525872]
CGMP-dependent protein kinase Target Info Inhibitor [551244]
Lck tyrosine kinase Target Info Inhibitor [525872]
Mitogen-activated protein kinase 14 Target Info Inhibitor [525872]
Mitogen-activated protein kinase 11 Target Info Inhibitor [525872]
Protein kinase C, alpha type Target Info Inhibitor [525872]
Mitogen-activated protein kinase 8 Target Info Inhibitor [525872]
MAP kinase p38 Target Info Inhibitor [525872]
RAC serine/threonine-protein kinase Target Info Inhibitor [525872]
Glycogen synthase kinase-3 beta Target Info Inhibitor [525872]
KEGG Pathway ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
TGF-beta signaling pathway
Fc gamma R-mediated phagocytosis
Insulin signaling pathway
Proteoglycans in cancer
Acute myeloid leukemia
Choline metabolism in cancerhsa04064:NF-kappa B signaling pathway
Osteoclast differentiation
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
HTLV-I infection
Primary immunodeficiencyhsa04010:MAPK signaling pathway
Rap1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Amyotrophic lateral sclerosis (ALS)
Epithelial cell signaling in Helicobacter pylori infection
Salmonella infection
Chagas disease (American trypanosomiasis)
Hepatitis C
Influenza A
Epstein-Barr virus infection
Proteoglycans in cancerhsa04010:MAPK signaling pathway
Ras signaling pathway
Calcium signaling pathway
Phosphatidylinositol signaling system
Vascular smooth muscle contraction
Wnt signaling pathway
Focal adhesion
Tight junction
Gap junction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Long-term depression
Insulin secretion
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
Pathogenic Escherichia coli infection
African trypanosomiasis
Hepatitis B
Pathways in cancer
MicroRNAs in cancer
Non-small cell lung cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
cAMP signaling pathway
Protein processing in endoplasmic reticulum
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Herpes simplex infection
Colorectal cancer
Pancreatic cancer
Oocyte meiosis
cGMP-PKG signaling pathway
Chemokine signaling pathway
Jak-STAT signaling pathway
B cell receptor signaling pathway
Estrogen signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Carbohydrate digestion and absorption
Renal cell carcinoma
Endometrial cancer
Prostate cancer
Chronic myeloid leukemia
Small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04012:ErbB signaling pathway
Cell cycle
Hedgehog signaling pathway
Axon guidance
Hippo signaling pathway
Alzheimer's disease
Basal cell carcinoma
NetPath Pathway TCR Signaling Pathway
IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
FSH Signaling Pathway
TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
TNFalpha Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_23:TSH Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
PDGF signaling pathway
PI3 kinase pathway
p53 pathway by glucose deprivation
CCKR signaling map STP00049:Parkinson disease
T cell activationP00003:Alzheimer disease-amyloid secretase pathway
B cell activation
EGF receptor signaling pathway
FGF signaling pathway
Interferon-gamma signaling pathway
Oxidative stress response
Parkinson disease
TGF-beta signaling pathway
Toll receptor signaling pathway
VEGF signaling pathway
Ras Pathway
p53 pathway feedback loops 2
p38 MAPK pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
p38 MAPK pathwayP00002:Alpha adrenergic receptor signaling pathway
Alzheimer disease-amyloid secretase pathway
Apoptosis signaling pathway
Endothelin signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
FAS signaling pathway
Integrin signalling pathway
T cell activation
p38 MAPK pathwayP00005:Angiogenesis
Huntington disease
Hypoxia response via HIF activation
Inflammation mediated by chemokine and cytokine signaling pathway
Insulin/IGF pathway-protein kinase B signaling cascade
Interleukin signaling pathway
p53 pathway
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Cadherin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
CCKR signaling map ST
Pathway Interaction Database Insulin Pathway
IL4-mediated signaling events
CDC42 signaling events
Angiopoietin receptor Tie2-mediated signaling
Regulation of Telomerase
mTOR signaling pathway
IGF1 pathway
IL2 signaling events mediated by PI3K
Integrins in angiogenesis
RXR and RAR heterodimerization with other nuclear receptor
Signaling events mediated by Stem cell factor receptor (c-Kit)
a6b1 and a6b4 Integrin signaling
TGF-beta receptor signalingnfkappabatypicalpathway:Atypical NF-kappaB pathway
Glypican 1 network
TCR signaling in na&#xef
Signaling events mediated by PTP1B
IL12-mediated signaling events
Regulation of p38-alpha and p38-beta
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
SHP2 signaling
IL2-mediated signaling events
CXCR4-mediated signaling events
Class I PI3K signaling events
amb2 Integrin signaling
EPHA forward signaling
PDGFR-beta signaling pathway
IL2 signaling events mediated by STAT5
Ephrin B reverse signaling
Alpha-synuclein signalingendothelinpathway:Endothelins
BCR signaling pathway
p73 transcription factor network
p38 MAPK signaling pathway
Atypical NF-kappaB pathway
CD40/CD40L signaling
FAS (CD95) signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Glucocorticoid receptor regulatory network
Rapid glucocorticoid signaling
Regulation of Androgen receptor activity
ATF-2 transcription factor network
IL6-mediated signaling events
p38 signaling mediated by MAPKAP kinases
Retinoic acid receptors-mediated signaling
CXCR3-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
EPO signaling pathway
Signaling events mediated by VEGFR1 and VEGFR2
p53 pathway
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
VEGFR3 signaling in lymphatic endothelium
FGF signaling pathway
RAC1 signaling pathway
Regulation of retinoblastoma proteinp73pathway:p73 transcription factor network
Plasma membrane estrogen receptor signaling
Regulation of retinoblastoma proteinendothelinpathway:Endothelins
Canonical NF-kappaB pathway
Signaling events regulated by Ret tyrosine kinase
Ras signaling in the CD4+ TCR pathway
ErbB1 downstream signaling
Syndecan-4-mediated signaling events
IL8- and CXCR2-mediated signaling events
VEGFR1 specific signals
PAR1-mediated thrombin signaling events
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
Downstream signaling in na&#xef
Fc-epsilon receptor I signaling in mast cells
RhoA signaling pathway
Noncanonical Wnt signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Osteopontin-mediated events
Reelin signaling pathway
TRAIL signaling pathway
IL1-mediated signaling events
FoxO family signaling
Ceramide signaling pathway
p75(NTR)-mediated signaling
ErbB2/ErbB3 signaling events
JNK signaling in the CD4+ TCR pathway
Nephrin/Neph1 signaling in the kidney podocyte
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Syndecan-2-mediated signaling events
N-cadherin signaling events
Signaling events mediated by focal adhesion kinase
Glypican 3 network
IL12 signaling mediated by STAT4rhoa_pathway:RhoA signaling pathway
Signaling mediated by p38-gamma and p38-deltasmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Fc-epsilon receptor I signaling in mast cells
LPA receptor mediated events
S1P3 pathway
Coregulation of Androgen receptor activity
Integrin-linked kinase signaling
FOXA2 and FOXA3 transcription factor networks
E-cadherin signaling in the nascent adherens junction
IFN-gamma pathway
E-cadherin signaling in keratinocytes
Signaling events mediated by the Hedgehog family
Nongenotropic Androgen signaling
Hedgehog signaling events mediated by Gli proteins
Caspase Cascade in Apoptosis
Aurora A signaling
Insulin-mediated glucose transport
Class I PI3K signaling events mediated by Akt
HIF-1-alpha transcription factor network
Trk receptor signaling mediated by PI3K and PLC-gamma
FGF signaling pathwaylysophospholipid_pathway:LPA receptor mediated events
Degradation of beta catenin
Presenilin action in Notch and Wnt signaling
LKB1 signaling events
Canonical Wnt signaling pathway
C-MYC pathway
BMP receptor signaling
Validated transcriptional targets of deltaNp63 isoforms
PathWhiz Pathway Leucine Stimulation on Insulin SignalingPW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Activation of PKC through G protein coupled receptorPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Fc Epsilon Receptor I Signaling in Mast Cells
Insulin Signalling
Leucine Stimulation on Insulin Signaling
Reactome mTORC1-mediated signallingR-HSA-114604:GPVI-mediated activation cascade
PIP3 activates AKT signaling
Regulation of KIT signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PD-1 signaling
Interleukin-2 signalingR-HSA-168638:NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Oxidative Stress Induced Senescence
CDO in myogenesis
DSCAM interactions
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-168638:NOD1/2 Signaling Pathway
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-111933:Calmodulin induced events
Disinhibition of SNARE formation
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+R-HSA-193648:NRAGE signals death through JNK
NRIF signals cell death from the nucleus
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksR-HSA-168638:NOD1/2 Signaling Pathway
VEGFA-VEGFR2 PathwayR-HSA-111447:Activation of BAD and translocation to mitochondria
GPVI-mediated activation cascade
Translocation of GLUT4 to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
eNOS activation
AKT-mediated inactivation of FOXO1A
Integrin alphaIIb beta3 signaling
Deactivation of the beta-catenin transactivating complex
G beta:gamma signalling through PI3Kgamma
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in CancerR-HSA-195253:Degradation of beta-catenin by the destruction complex
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
Degradation of GLI2 by the proteasome
Constitutive Signaling by AKT1 E17K in Cancer
WikiPathways ErbB Signaling Pathway
Interferon type I signaling pathways
G13 Signaling Pathway
IL-2 Signaling Pathway
Insulin Signaling
Cytoplasmic Ribosomal Proteins
EGF/EGFR Signaling Pathway
IL-4 Signaling Pathway
IL-6 signaling pathway
Kit receptor signaling pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
BDNF signaling pathway
Interleukin-11 Signaling Pathway
FSH signaling pathway
Leptin signaling pathway
TSH signaling pathway
Signaling by Insulin receptor
TOR Signaling
AMPK Signaling
IL-5 Signaling PathwayWP61:Notch Signaling Pathway
Inflammatory Response Pathway
Signaling by SCF-KIT
DAP12 interactions
Host Interactions of HIV factors
PIP3 activates AKT signaling
T-Cell Receptor and Co-stimulatory Signaling
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
TCR signaling
Costimulation by the CD28 familyWP75:Toll-like receptor signaling pathway
Monoamine Transport
Serotonin HTR1 Group and FOS Pathway
TCR Signaling Pathway
Senescence and Autophagy in Cancer
MAPK Cascade
Oxidative Stress
p38 MAPK Signaling Pathway
MAPK Signaling Pathway
TGF beta Signaling Pathway
Cardiac Hypertrophic Response
MAP kinase activation in TLR cascade
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
Amyotrophic lateral sclerosis (ALS)
Alpha 6 Beta 4 signaling pathway
Cardiac Progenitor Differentiation
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Parkinsons Disease Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
Prostate Cancer
TWEAK Signaling Pathway
RANKL/RANK Signaling Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
IL-1 signaling pathway
Signal amplification
Platelet homeostasis
NGF signalling via TRKA from the plasma membrane
DSCAM interactions
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathwayWP673:ErbB Signaling Pathway
Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Wnt Signaling Pathway Netpath
G Protein Signaling Pathways
Transcriptional activation by NRF2
Myometrial Relaxation and Contraction Pathways
Human Complement System
Syndecan interactions
DAG and IP3 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Pathogenic Escherichia coli infection
Signaling Pathways in Glioblastoma
Endothelin Pathways
Regulation of Microtubule Cytoskeleton
miRs in Muscle Cell Differentiation
Opioid Signalling
Response to elevated platelet cytosolic Ca2+
Integration of energy metabolism
TOR SignalingWP75:Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
FAS pathway and Stress induction of HSP regulation
Signaling of Hepatocyte Growth Factor Receptor
NLR Proteins
IL-3 Signaling Pathway
EBV LMP1 signaling
PDGF Pathway
Nanoparticle triggered regulated necrosis
TNF alpha Signaling Pathway
Signalling by NGF
Intrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
Type II diabetes mellitus
Regulation of toll-like receptor signaling pathway
Osteoclast SignalingWP75:Toll-like receptor signaling pathway
Signal Transduction of S1P Receptor
Integrin-mediated Cell Adhesion
Notch Signaling Pathway
EPO Receptor Signaling
Endochondral Ossification
Copper homeostasis
Extracellular vesicle-mediated signaling in recipient cells
Translocation of GLUT4 to the Plasma Membrane
Primary Focal Segmental Glomerulosclerosis FSGS
IL17 signaling pathway
IL-7 Signaling Pathway
Integrated Breast Cancer Pathway
SREBP signalling
Integrated Cancer pathway
Metabolism of nitric oxide
TFs Regulate miRNAs related to cardiac hypertrophy
Androgen receptor signaling pathway
IL-5 Signaling PathwayWP710:DNA Damage Response (only ATM dependent)
Glycogen Metabolism
Focal Adhesion
Hair Follicle Development: Induction (Part 1 of 3)
Degradation of beta-catenin by the destruction complex
Neural Crest Differentiation
Alzheimers Disease
Semaphorin interactions
Cell Cycle
IL-5 Signaling Pathway
Ref 525872Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Ref 525872Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Ref 551244Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C, Bioorg. Med. Chem. Lett. 3(10):1959-1964 (1993).

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