Drug General Information
Drug ID	D0GL7H
Former ID	DIB001392
Drug Name	Talotrexin
Synonyms	Talvesta; Talotrexin ammonium; PT-523; PT-633; 10-deaza-PT-523
Drug Type	Small molecular drug
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 1/2	[521643]
Company	Hana Biosciences; Dana-Farber Cancer Institute Inc
Structure		Download 2D MOL 3D MOL
Formula	C27H27N9O6
Canonical SMILES	n1c(c2c(nc1N)ncc(n2)CNc1ccc(C(=O)N[C@H](C(=O)O)CCCNC(=O<br />)c2c(C(=O)O)cccc2)cc1)N
PubChem Compound ID	130731
Target and Pathway
Target(s)	Folate receptor alpha	Target Info	Antagonist	[544163]
KEGG Pathway	Endocytosis
Reactome	COPII (Coat Protein 2) Mediated Vesicle Transport
	Cargo concentration in the ER
WikiPathways	Folate Metabolism
References
Ref 521643	ClinicalTrials.gov (NCT00112060) A Study to Assess the Safety and Preliminary Efficacy of PT-523 in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC). U.S. National Institutes of Health.
Ref 544163	Cancer chemotherapy: targeting folic acid synthesis. Cancer Manag Res. 2010; 2: 293-301.

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