Drug General Information
Drug ID
D0GP7D
Former ID
DNC011378
Drug Name
NSC-119911
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531262]
Structure
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2D MOL

3D MOL

Formula
C16H10O7
Canonical SMILES
C1=CC(=C(C2=C1C(=C3C=CC(=O)C(=C3O2)O)C=CC(=O)O)O)O
InChI
1S/C16H10O7/c17-10-4-1-8-7(3-6-12(19)20)9-2-5-11(18)14(22)16(9)23-15(8)13(10)21/h1-6,17,21-22H,(H,19,20)/b6-3+
InChIKey
HVUVBNCTBKJHHZ-ZZXKWVIFSA-N
PubChem Compound ID
Target and Pathway
Target(s) 73-kDa molecular chaperone HSP73 Target Info Inhibitor [531262]
Heat shock protein 70 Target Info Inhibitor [531262]
KEGG Pathway Spliceosome
MAPK signaling pathway
Protein processing in endoplasmic reticulum
Endocytosis
Antigen processing and presentation
Estrogen signaling pathway
Legionellosis
Toxoplasmosis
Measles
Influenza A
Epstein-Barr virus infection
NetPath Pathway TCR Signaling Pathway
TSH Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Parkinson disease
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
C-MYB transcription factor network
Reactome Regulation of HSF1-mediated heat shock response
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
CHL1 interactions
mRNA Splicing - Major Pathway
WikiPathways Diurnally Regulated Genes with Circadian Orthologs
MAPK Signaling Pathway
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
GABA synthesis, release, reuptake and degradation
Parkin-Ubiquitin Proteasomal System pathway
Membrane Trafficking
L1CAM interactions
References
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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