| Drug General Information |
| Drug ID |
D0GR5L
|
| Former ID |
DNC003681
|
| Drug Name |
AL-43
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C23H25NO2
|
| Canonical SMILES |
CC1=CC(NC2=C1C3=C(C=C2)C4=C(C=CC=C4OC)OC3CC=C)(C)C
|
| InChI |
1S/C23H25NO2/c1-6-8-18-22-15(21-17(25-5)9-7-10-19(21)26-18)11-12-16-20(22)14(2)13-23(3,4)24-16/h6-7,9-13,18,24H,1,8H2,2-5H3
|
| InChIKey |
CZSDJYXNNJQXBB-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
mRNA of glucocorticoid receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| mRNA of androgen receptor |
Target Info |
Inhibitor |
[1]
|
| Progesterone receptor |
Target Info |
Inhibitor |
[1]
|
| Mineralocorticoid receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interactionhsa04114:Oocyte meiosis
|
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Pathways in cancer
|
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Prostate cancerhsa04114:Oocyte meiosis
|
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Progesterone-mediated oocyte maturationhsa04960:Aldosterone-regulated sodium reabsorption
|
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NetPath Pathway
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IL2 Signaling Pathway
|
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TCR Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
|
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AndrogenReceptor Signaling Pathway
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FSH Signaling Pathway
|
|
Pathway Interaction Database
|
Regulation of nuclear SMAD2/3 signaling
|
|
Signaling events mediated by HDAC Class II
|
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FOXA2 and FOXA3 transcription factor networks
|
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Glucocorticoid receptor regulatory network
|
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Regulation of Androgen receptor activity
|
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AP-1 transcription factor networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
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Coregulation of Androgen receptor activity
|
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Nongenotropic Androgen signaling
|
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Regulation of nuclear beta catenin signaling and target gene transcription
|
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FOXA1 transcription factor network
|
|
Notch-mediated HES/HEY networkanthraxpathway:Cellular roles of Anthrax toxin
|
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PathWhiz Pathway
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Kidney Function
|
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Reactome
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BMAL1:CLOCK,NPAS2 activates circadian gene expressionR-HSA-383280:Nuclear Receptor transcription pathway
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Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-1251985:Nuclear signaling by ERBB4
|
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Nuclear Receptor transcription pathway
|
|
WikiPathways
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Serotonin Receptor 4/6/7 and NR3C Signaling
|
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SIDS Susceptibility Pathways
|
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Endoderm Differentiation
|
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Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
|
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Adipogenesis
|
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Circadian Clock
|
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Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
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Integrated Pancreatic Cancer Pathway
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Prostate Cancer
|
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Integrated Breast Cancer Pathway
|
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Nuclear Receptors
|
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Androgen receptor signaling pathwayWP34:Ovarian Infertility Genes
|
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Signaling by ERBB4
|
|
Nuclear ReceptorsWP554:ACE Inhibitor Pathway
|
| References |
| REF 1 | J Med Chem. 2003 Mar 13;46(6):1016-30.Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines. |
|---|
| REF 2 | Bioorg Med Chem Lett. 2004 Apr 5;14(7):1721-7.Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators. |
|---|
