TTD | Drug: D0GT8N

Drug General Information
Drug ID	D0GT8N
Former ID	DNC009917
Drug Name	NM-PP1
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541287]
Structure		Download 2D MOL 3D MOL
Formula	C20H21N5
InChI	InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23)
InChIKey	GDQXJQSQYMMKRA-UHFFFAOYSA-N
PubChem Compound ID	5154691
PubChem Substance ID	7652214, 8577944, 14777531, 26759391, 39002667, 49645644, 49815672, 53800582, 57581434, 58608236, 76556496, 99302765, 103694299, 104139756, 113776121, 124792262, 125333804, 127938937, 134347122, 140290968, 144080829, 152343755, 162254028, 163124445, 163663961, 163687462, 163726964, 170558538, 174006637, 175607432, 178102650, 178111817, 179042910, 204361342, 208012745, 208013107, 208264803, 208265645, 210275013, 210280651, 223394633, 228125047, 250134311, 251910631, 252160545, 252214173, 252229221, 252457406, 252465372, 252672132
Target and Pathway
Target(s)	mRNA of human RIP2	Target Info	Inhibitor	[529039]
	Mitogen-activated protein kinase 8	Target Info	Inhibitor	[529039]
	mRNA of PKA Catalytic Subunit C-alpha	Target Info	Inhibitor	[529039]
	Proto-oncogene tyrosine-protein kinase SRC	Target Info	Inhibitor	[529039]
	Lck tyrosine kinase	Target Info	Inhibitor	[529039]
KEGG Pathway	NOD-like receptor signaling pathway
	Neurotrophin signaling pathway
	Shigellosis
	Tuberculosishsa04010:MAPK signaling pathway
	ErbB signaling pathway
	Ras signaling pathway
	cAMP signaling pathway
	FoxO signaling pathway
	Sphingolipid signaling pathway
	Protein processing in endoplasmic reticulum
	Wnt signaling pathway
	Osteoclast differentiation
	Focal adhesion
	Toll-like receptor signaling pathway
	RIG-I-like receptor signaling pathway
	Fc epsilon RI signaling pathway
	TNF signaling pathway
	Retrograde endocannabinoid signaling
	Dopaminergic synapse
	Inflammatory mediator regulation of TRP channels
	Insulin signaling pathway
	GnRH signaling pathway
	Progesterone-mediated oocyte maturation
	Prolactin signaling pathway
	Adipocytokine signaling pathway
	Type II diabetes mellitus
	Non-alcoholic fatty liver disease (NAFLD)
	Epithelial cell signaling in Helicobacter pylori infection
	Salmonella infection
	Pertussis
	Chagas disease (American trypanosomiasis)
	Toxoplasmosis
	Tuberculosis
	Hepatitis C
	Hepatitis B
	Influenza A
	HTLV-I infection
	Herpes simplex infection
	Epstein-Barr virus infection
	Pathways in cancer
	Colorectal cancer
	Pancreatic cancer
	Choline metabolism in cancerhsa04010:MAPK signaling pathway
	Calcium signaling pathway
	Chemokine signaling pathway
	Oocyte meiosis
	Apoptosis
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Hedgehog signaling pathway
	Gap junction
	Platelet activation
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Cholinergic synapse
	Serotonergic synapse
	GABAergic synapse
	Olfactory transduction
	Taste transduction
	Insulin secretion
	Ovarian steroidogenesis
	Estrogen signaling pathway
	Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Renin secretion
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Salivary secretion
Gastric acid secretion
Bile secretion
Parkinson's disease
Prion diseases
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
Vibrio cholerae infection
Amoebiasis
Viral carcinogenesis
Proteoglycans in cancer
Dilated cardiomyopathyhsa04012:ErbB signaling pathway
Rap1 signaling pathway
Endocytosis
VEGF signaling pathway
Adherens junction
Tight junction
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Proteoglycans in cancerhsa04064:NF-kappa B signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Primary immunodeficiency
NetPath Pathway	IL4 Signaling Pathway
	TNFalpha Signaling PathwayNetPath_17:IL5 Signaling Pathway
	TNFalpha Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
	IL2 Signaling Pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Angiogenesis
	Apoptosis signaling pathway
	B cell activation
	FAS signaling pathway
	Integrin signalling pathway
	Interferon-gamma signaling pathway
	Oxidative stress response
	PDGF signaling pathway
	Parkinson disease
	TGF-beta signaling pathway
	T cell activation
	Toll receptor signaling pathway
	Ras Pathway
	CCKR signaling map STP00019:Endothelin signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
	Inflammation mediated by chemokine and cytokine signaling pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group II pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	5HT1 type receptor mediated signaling pathway
	Beta1 adrenergic receptor signaling pathway
	Beta2 adrenergic receptor signaling pathway
	Histamine H2 receptor mediated signaling pathway
	GABA-B receptor II signaling
	Dopamine receptor mediated signaling pathway
	Enkephalin release
	Nicotine pharmacodynamics pathway
	CCKR signaling map STP00005:Angiogenesis
	Cadherin signaling pathway
	CCKR signaling map STP00049:Parkinson disease
Pathway Interaction Database	Canonical NF-kappaB pathway
	IL12-mediated signaling events
	p75(NTR)-mediated signalingfcer1pathway:Fc-epsilon receptor I signaling in mast cells
	Endothelins
	BCR signaling pathway
	RhoA signaling pathway
	Noncanonical Wnt signaling pathway
	CD40/CD40L signaling
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	Osteopontin-mediated events
	Reelin signaling pathway
	TRAIL signaling pathway
	CDC42 signaling events
	Signaling events regulated by Ret tyrosine kinase
	Angiopoietin receptor Tie2-mediated signaling
	FAS (CD95) signaling pathway
	IL1-mediated signaling events
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	Glucocorticoid receptor regulatory network
	IL2-mediated signaling events
	Rapid glucocorticoid signaling
	FoxO family signaling
	Ceramide signaling pathway
	Regulation of Androgen receptor activity
	p75(NTR)-mediated signaling
	ErbB1 downstream signaling
	ATF-2 transcription factor network
	ErbB2/ErbB3 signaling events
	PDGFR-beta signaling pathway
	JNK signaling in the CD4+ TCR pathway
	Nephrin/Neph1 signaling in the kidney podocyte
	HIV-1 Nef: Negative effector of Fas and TNF-alpha
	Retinoic acid receptors-mediated signaling
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	EPO signaling pathway
	Syndecan-2-mediated signaling events
	Ephrin B reverse signaling
	p53 pathway
	N-cadherin signaling events
	S1P2 pathway
	Downstream signaling in na&#xef
	RAC1 signaling pathway
	Signaling events mediated by focal adhesion kinase
	Glypican 3 network
	IL12 signaling mediated by STAT4gmcsf_pathway:GMCSF-mediated signaling events
	LPA4-mediated signaling events
	LKB1 signaling events
	Thromboxane A2 receptor signaling
	SHP2 signaling
	Signaling events mediated by HDAC Class I
	IL3-mediated signaling events
	Syndecan-1-mediated signaling events
	Hedgehog signaling events mediated by Gli proteins
	VEGFR1 specific signals
	Calcium signaling in the CD4+ TCR pathway
	Signaling events mediated by VEGFR1 and VEGFR2
	Aurora A signaling
	Class I PI3K signaling events mediated by Akt
	Alpha4 beta1 integrin signaling eventsendothelinpathway:Endothelins
	Signaling events mediated by PRL
	LPA receptor mediated events
	Atypical NF-kappaB pathway
	Glypican 1 network
	Plasma membrane estrogen receptor signaling
Signaling events mediated by PTP1B
S1P3 pathway
EPHB forward signaling
Nectin adhesion pathway
Regulation of p38-alpha and p38-beta
Arf6 signaling events
Signaling events mediated by TCPTP
Netrin-mediated signaling events
Alpha9 beta1 integrin signaling events
CXCR4-mediated signaling events
EGF receptor (ErbB1) signaling pathway
Class I PI3K signaling events
Posttranslational regulation of adherens junction stability and dissassembly
E-cadherin signaling in the nascent adherens junction
amb2 Integrin signaling
Integrins in angiogenesis
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
EPHA forward signaling
E-cadherin signaling in keratinocytes
Nongenotropic Androgen signaling
Internalization of ErbB1
CXCR3-mediated signaling events
Syndecan-3-mediated signaling events
Trk receptor signaling mediated by PI3K and PLC-gamma
EPHA2 forward signaling
Alpha-synuclein signaling
FGF signaling pathway
Alpha4 beta1 integrin signaling events
Signaling events mediated by focal adhesion kinasenfkappabatypicalpathway:Atypical NF-kappaB pathway
TCR signaling in na&#xef
TCR signaling in na&#xef
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
	Fc Epsilon Receptor I Signaling in Mast CellsPW000564:Muscle/Heart Contraction
Reactome	NOD1/2 Signaling Pathway
	p75NTR recruits signalling complexes
	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
	Interleukin-1 signaling
	activated TAK1 mediates p38 MAPK activation
	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1R-HSA-193648:NRAGE signals death through JNK
	NRIF signals cell death from the nucleus
	Oxidative Stress Induced Senescence
	FCERI mediated MAPK activation
	DSCAM interactions
	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
	Activation of the AP-1 family of transcription factors
	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksR-HSA-163560:Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
	PKA activation
	PKA activation in glucagon signalling
	DARPP-32 events
	Regulation of PLK1 Activity at G2/M Transition
	Loss of Nlp from mitotic centrosomes
	Recruitment of mitotic centrosome proteins and complexes
	Loss of proteins required for interphase microtubule organization?from the centrosome
	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
	Regulation of insulin secretion
	Vasopressin regulates renal water homeostasis via Aquaporins
	VEGFA-VEGFR2 Pathway
	Interleukin-3, 5 and GM-CSF signaling
	Degradation of GLI1 by the proteasome
	Degradation of GLI2 by the proteasome
	Hedgehog 'off' state
	Anchoring of the basal body to the plasma membrane
	CD209 (DC-SIGN) signaling
	MAPK6/MAPK4 signaling
	Gluconeogenesis
	Factors involved in megakaryocyte development and platelet productionR-HSA-114604:GPVI-mediated activation cascade
	PIP3 activates AKT signaling
	Regulation of KIT signaling
	Phosphorylation of CD3 and TCR zeta chains
	Translocation of ZAP-70 to Immunological synapse
	Generation of second messenger molecules
	PECAM1 interactions
	Constitutive Signaling by Aberrant PI3K in Cancer
	DAP12 signaling
	CD28 co-stimulation
	CD28 dependent PI3K/Akt signaling
	CD28 dependent Vav1 pathway
	CTLA4 inhibitory signaling
	PD-1 signaling
	Interleukin-2 signaling
WikiPathways	TCR Signaling Pathway
	FAS pathway and Stress induction of HSP regulation
	Apoptosis-related network due to altered Notch3 in ovarian cancer
	MAP kinase activation in TLR cascade
	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
	Signalling by NGF
	TCR signaling
	Interleukin-1 signaling
	NOD pathwayWP75:Toll-like receptor signaling pathway
	DNA Damage Response (only ATM dependent)
	ErbB Signaling Pathway
	Insulin Signaling
	EGF/EGFR Signaling Pathway
	MAPK Signaling Pathway
	TGF beta Signaling Pathway
	Signaling of Hepatocyte Growth Factor Receptor
	Kit receptor signaling pathway
	Transcriptional activation by NRF2
	NLR Proteins
	IL-3 Signaling Pathway
	Cardiac Hypertrophic Response
	Nanoparticle-mediated activation of receptor signaling
	Structural Pathway of Interleukin 1 (IL-1)
	EBV LMP1 signaling
	JAK/STAT
	PDGF Pathway
	Nanoparticle triggered regulated necrosis
	BDNF signaling pathway
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Corticotropin-releasing hormone
	AGE/RAGE pathway
	TNF alpha Signaling Pathway
	B Cell Receptor Signaling Pathway
	Prostate Cancer
	TSLP Signaling Pathway
	TWEAK Signaling Pathway
	Leptin signaling pathway
	RANKL/RANK Signaling Pathway
	IL-1 signaling pathway
	Intrinsic Pathway for Apoptosis
	DSCAM interactions
	Apoptosis Modulation and Signaling
	Type II diabetes mellitus
	MicroRNAs in cardiomyocyte hypertrophy
	Physiological and Pathological Hypertrophy of the Heart
	Regulation of toll-like receptor signaling pathway
	Osteoclast SignalingWP706:SIDS Susceptibility Pathways
	Hypothetical Network for Drug Addiction
	Calcium Regulation in the Cardiac Cell
	Endochondral Ossification
	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	Mesodermal Commitment Pathway
	Human Complement System
	DAG and IP3 signaling
	Regulation of Water Balance by Renal Aquaporins
	Dopamine metabolism
	Regulation of Microtubule Cytoskeleton
	FSH signaling pathway
	miRs in Muscle Cell Differentiation
	SREBP signalling
	Opioid Signalling
Mitotic G2-G2/M phases
Integration of energy metabolism
Factors involved in megakaryocyte development and platelet production
Nicotine Activity on Dopaminergic NeuronsWP673:ErbB Signaling Pathway
Senescence and Autophagy in Cancer
Notch Signaling Pathway
EPO Receptor Signaling
Pregnane X Receptor pathway
Aryl Hydrocarbon Receptor Pathway
Polycystic Kidney Disease Pathway
Alpha 6 Beta 4 signaling pathway
Interleukin-11 Signaling Pathway
Signaling Pathways in Glioblastoma
Arylhydrocarbon receptor (AhR) signaling pathway
Integrin-mediated Cell Adhesion
Angiogenesis
Androgen receptor signaling pathwayWP61:Notch Signaling Pathway
Interferon type I signaling pathways
IL-2 Signaling Pathway
Inflammatory Response Pathway
Signaling by SCF-KIT
DAP12 interactions
Host Interactions of HIV factors
PIP3 activates AKT signaling
T-Cell Receptor and Co-stimulatory Signaling
Costimulation by the CD28 family
References
Ref 541287	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6028).
Ref 529039	Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update.

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Prof. Feng ZHU

Prof. Yuzong CHEN