| Drug General Information |
| Drug ID |
D0GT8N
|
| Former ID |
DNC009917
|
| Drug Name |
NM-PP1
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H21N5
|
| InChI |
InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23)
|
| InChIKey |
GDQXJQSQYMMKRA-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
7652214, 8577944, 14777531, 26759391, 39002667, 49645644, 49815672, 53800582, 57581434, 58608236, 76556496, 99302765, 103694299, 104139756, 113776121, 124792262, 125333804, 127938937, 134347122, 140290968, 144080829, 152343755, 162254028, 163124445, 163663961, 163687462, 163726964, 170558538, 174006637, 175607432, 178102650, 178111817, 179042910, 204361342, 208012745, 208013107, 208264803, 208265645, 210275013, 210280651, 223394633, 228125047, 250134311, 251910631, 252160545, 252214173, 252229221, 252457406, 252465372, 252672132
|
| Target and Pathway |
| Target(s) |
mRNA of human RIP2 |
Target Info |
Inhibitor |
[2]
|
|---|
| Mitogen-activated protein kinase 8 |
Target Info |
Inhibitor |
[2]
|
| mRNA of PKA Catalytic Subunit C-alpha |
Target Info |
Inhibitor |
[2]
|
| Proto-oncogene tyrosine-protein kinase SRC |
Target Info |
Inhibitor |
[2]
|
| Lck tyrosine kinase |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
NOD-like receptor signaling pathway
|
|
Neurotrophin signaling pathway
|
|
Shigellosis
|
|
Tuberculosishsa04010:MAPK signaling pathway
|
|
ErbB signaling pathway
|
|
Ras signaling pathway
|
|
cAMP signaling pathway
|
|
FoxO signaling pathway
|
|
Sphingolipid signaling pathway
|
|
Protein processing in endoplasmic reticulum
|
|
Wnt signaling pathway
|
|
Osteoclast differentiation
|
|
Focal adhesion
|
|
Toll-like receptor signaling pathway
|
|
RIG-I-like receptor signaling pathway
|
|
Fc epsilon RI signaling pathway
|
|
TNF signaling pathway
|
|
Retrograde endocannabinoid signaling
|
|
Dopaminergic synapse
|
|
Inflammatory mediator regulation of TRP channels
|
|
Insulin signaling pathway
|
|
GnRH signaling pathway
|
|
Progesterone-mediated oocyte maturation
|
|
Prolactin signaling pathway
|
|
Adipocytokine signaling pathway
|
|
Type II diabetes mellitus
|
|
Non-alcoholic fatty liver disease (NAFLD)
|
|
Epithelial cell signaling in Helicobacter pylori infection
|
|
Salmonella infection
|
|
Pertussis
|
|
Chagas disease (American trypanosomiasis)
|
|
Toxoplasmosis
|
|
Tuberculosis
|
|
Hepatitis C
|
|
Hepatitis B
|
|
Influenza A
|
|
HTLV-I infection
|
|
Herpes simplex infection
|
|
Epstein-Barr virus infection
|
|
Pathways in cancer
|
|
Colorectal cancer
|
|
Pancreatic cancer
|
|
Choline metabolism in cancerhsa04010:MAPK signaling pathway
|
|
Calcium signaling pathway
|
|
Chemokine signaling pathway
|
|
Oocyte meiosis
|
|
Apoptosis
|
|
Adrenergic signaling in cardiomyocytes
|
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Vascular smooth muscle contraction
|
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Hedgehog signaling pathway
|
|
Gap junction
|
|
Platelet activation
|
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Circadian entrainment
|
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Long-term potentiation
|
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Glutamatergic synapse
|
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Cholinergic synapse
|
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Serotonergic synapse
|
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GABAergic synapse
|
|
Olfactory transduction
|
|
Taste transduction
|
|
Insulin secretion
|
|
Ovarian steroidogenesis
|
|
Estrogen signaling pathway
|
|
Melanogenesis
|
|
Thyroid hormone synthesis
|
|
Thyroid hormone signaling pathway
|
|
Oxytocin signaling pathway
|
|
Glucagon signaling pathway
|
|
Regulation of lipolysis in adipocytes
|
|
Renin secretion
|
|
Endocrine and other factor-regulated calcium reabsorption
|
|
Vasopressin-regulated water reabsorption
|
|
Salivary secretion
|
|
Gastric acid secretion
|
|
Bile secretion
|
|
Parkinson's disease
|
|
Prion diseases
|
|
Cocaine addiction
|
|
Amphetamine addiction
|
|
Morphine addiction
|
|
Alcoholism
|
|
Vibrio cholerae infection
|
|
Amoebiasis
|
|
Viral carcinogenesis
|
|
Proteoglycans in cancer
|
|
Dilated cardiomyopathyhsa04012:ErbB signaling pathway
|
|
Rap1 signaling pathway
|
|
Endocytosis
|
|
VEGF signaling pathway
|
|
Adherens junction
|
|
Tight junction
|
|
Regulation of actin cytoskeleton
|
|
Bacterial invasion of epithelial cells
|
|
Proteoglycans in cancerhsa04064:NF-kappa B signaling pathway
|
|
Natural killer cell mediated cytotoxicity
|
|
T cell receptor signaling pathway
|
|
Primary immunodeficiency
|
|
NetPath Pathway
|
IL4 Signaling Pathway
|
|
TNFalpha Signaling PathwayNetPath_17:IL5 Signaling Pathway
|
|
TNFalpha Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
|
|
IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Angiogenesis
|
|
Apoptosis signaling pathway
|
|
B cell activation
|
|
FAS signaling pathway
|
|
Integrin signalling pathway
|
|
Interferon-gamma signaling pathway
|
|
Oxidative stress response
|
|
PDGF signaling pathway
|
|
Parkinson disease
|
|
TGF-beta signaling pathway
|
|
T cell activation
|
|
Toll receptor signaling pathway
|
|
Ras Pathway
|
|
CCKR signaling map STP00019:Endothelin signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
|
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Metabotropic glutamate receptor group III pathway
|
|
Metabotropic glutamate receptor group II pathway
|
|
Metabotropic glutamate receptor group I pathway
|
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
|
|
5HT1 type receptor mediated signaling pathway
|
|
Beta1 adrenergic receptor signaling pathway
|
|
Beta2 adrenergic receptor signaling pathway
|
|
Histamine H2 receptor mediated signaling pathway
|
|
GABA-B receptor II signaling
|
|
Dopamine receptor mediated signaling pathway
|
|
Enkephalin release
|
|
Nicotine pharmacodynamics pathway
|
|
CCKR signaling map STP00005:Angiogenesis
|
|
Cadherin signaling pathway
|
|
CCKR signaling map STP00049:Parkinson disease
|
|
Pathway Interaction Database
|
Canonical NF-kappaB pathway
|
|
IL12-mediated signaling events
|
|
p75(NTR)-mediated signalingfcer1pathway:Fc-epsilon receptor I signaling in mast cells
|
|
Endothelins
|
|
BCR signaling pathway
|
|
RhoA signaling pathway
|
|
Noncanonical Wnt signaling pathway
|
|
CD40/CD40L signaling
|
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
Osteopontin-mediated events
|
|
Reelin signaling pathway
|
|
TRAIL signaling pathway
|
|
CDC42 signaling events
|
|
Signaling events regulated by Ret tyrosine kinase
|
|
Angiopoietin receptor Tie2-mediated signaling
|
|
FAS (CD95) signaling pathway
|
|
IL1-mediated signaling events
|
|
Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
|
Glucocorticoid receptor regulatory network
|
|
IL2-mediated signaling events
|
|
Rapid glucocorticoid signaling
|
|
FoxO family signaling
|
|
Ceramide signaling pathway
|
|
Regulation of Androgen receptor activity
|
|
p75(NTR)-mediated signaling
|
|
ErbB1 downstream signaling
|
|
ATF-2 transcription factor network
|
|
ErbB2/ErbB3 signaling events
|
|
PDGFR-beta signaling pathway
|
|
JNK signaling in the CD4+ TCR pathway
|
|
Nephrin/Neph1 signaling in the kidney podocyte
|
|
HIV-1 Nef: Negative effector of Fas and TNF-alpha
|
|
Retinoic acid receptors-mediated signaling
|
|
Signaling events mediated by Stem cell factor receptor (c-Kit)
|
|
EPO signaling pathway
|
|
Syndecan-2-mediated signaling events
|
|
Ephrin B reverse signaling
|
|
p53 pathway
|
|
N-cadherin signaling events
|
|
S1P2 pathway
|
|
Downstream signaling in naï
|
|
RAC1 signaling pathway
|
|
Signaling events mediated by focal adhesion kinase
|
|
Glypican 3 network
|
|
IL12 signaling mediated by STAT4gmcsf_pathway:GMCSF-mediated signaling events
|
|
LPA4-mediated signaling events
|
|
LKB1 signaling events
|
|
Thromboxane A2 receptor signaling
|
|
SHP2 signaling
|
|
Signaling events mediated by HDAC Class I
|
|
IL3-mediated signaling events
|
|
Syndecan-1-mediated signaling events
|
|
Hedgehog signaling events mediated by Gli proteins
|
|
VEGFR1 specific signals
|
|
Calcium signaling in the CD4+ TCR pathway
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Aurora A signaling
|
|
Class I PI3K signaling events mediated by Akt
|
|
Alpha4 beta1 integrin signaling eventsendothelinpathway:Endothelins
|
|
Signaling events mediated by PRL
|
|
LPA receptor mediated events
|
|
Atypical NF-kappaB pathway
|
|
Glypican 1 network
|
|
Plasma membrane estrogen receptor signaling
|
|
Signaling events mediated by PTP1B
|
|
S1P3 pathway
|
|
EPHB forward signaling
|
|
Nectin adhesion pathway
|
|
Regulation of p38-alpha and p38-beta
|
|
Arf6 signaling events
|
|
Signaling events mediated by TCPTP
|
|
Netrin-mediated signaling events
|
|
Alpha9 beta1 integrin signaling events
|
|
CXCR4-mediated signaling events
|
|
EGF receptor (ErbB1) signaling pathway
|
|
Class I PI3K signaling events
|
|
Posttranslational regulation of adherens junction stability and dissassembly
|
|
E-cadherin signaling in the nascent adherens junction
|
|
amb2 Integrin signaling
|
|
Integrins in angiogenesis
|
|
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
|
EPHA forward signaling
|
|
E-cadherin signaling in keratinocytes
|
|
Nongenotropic Androgen signaling
|
|
Internalization of ErbB1
|
|
CXCR3-mediated signaling events
|
|
Syndecan-3-mediated signaling events
|
|
Trk receptor signaling mediated by PI3K and PLC-gamma
|
|
EPHA2 forward signaling
|
|
Alpha-synuclein signaling
|
|
FGF signaling pathway
|
|
Alpha4 beta1 integrin signaling events
|
|
Signaling events mediated by focal adhesion kinasenfkappabatypicalpathway:Atypical NF-kappaB pathway
|
|
TCR signaling in naï
|
|
TCR signaling in naï
|
|
IL2 signaling events mediated by PI3K
|
|
IL2 signaling events mediated by STAT5
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Fc Epsilon Receptor I Signaling in Mast CellsPW000564:Muscle/Heart Contraction
|
|
Reactome
|
NOD1/2 Signaling Pathway
|
|
p75NTR recruits signalling complexes
|
|
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
|
|
Interleukin-1 signaling
|
|
activated TAK1 mediates p38 MAPK activation
|
|
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1R-HSA-193648:NRAGE signals death through JNK
|
|
NRIF signals cell death from the nucleus
|
|
Oxidative Stress Induced Senescence
|
|
FCERI mediated MAPK activation
|
|
DSCAM interactions
|
|
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
|
|
Activation of the AP-1 family of transcription factors
|
|
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksR-HSA-163560:Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
|
|
PKA activation
|
|
PKA activation in glucagon signalling
|
|
DARPP-32 events
|
|
Regulation of PLK1 Activity at G2/M Transition
|
|
Loss of Nlp from mitotic centrosomes
|
|
Recruitment of mitotic centrosome proteins and complexes
|
|
Loss of proteins required for interphase microtubule organization?from the centrosome
|
|
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
|
|
Regulation of insulin secretion
|
|
Vasopressin regulates renal water homeostasis via Aquaporins
|
|
VEGFA-VEGFR2 Pathway
|
|
Interleukin-3, 5 and GM-CSF signaling
|
|
Degradation of GLI1 by the proteasome
|
|
Degradation of GLI2 by the proteasome
|
|
Hedgehog 'off' state
|
|
Anchoring of the basal body to the plasma membrane
|
|
CD209 (DC-SIGN) signaling
|
|
MAPK6/MAPK4 signaling
|
|
Gluconeogenesis
|
|
Factors involved in megakaryocyte development and platelet productionR-HSA-114604:GPVI-mediated activation cascade
|
|
PIP3 activates AKT signaling
|
|
Regulation of KIT signaling
|
|
Phosphorylation of CD3 and TCR zeta chains
|
|
Translocation of ZAP-70 to Immunological synapse
|
|
Generation of second messenger molecules
|
|
PECAM1 interactions
|
|
Constitutive Signaling by Aberrant PI3K in Cancer
|
|
DAP12 signaling
|
|
CD28 co-stimulation
|
|
CD28 dependent PI3K/Akt signaling
|
|
CD28 dependent Vav1 pathway
|
|
CTLA4 inhibitory signaling
|
|
PD-1 signaling
|
|
Interleukin-2 signaling
|
|
WikiPathways
|
TCR Signaling Pathway
|
|
FAS pathway and Stress induction of HSP regulation
|
|
Apoptosis-related network due to altered Notch3 in ovarian cancer
|
|
MAP kinase activation in TLR cascade
|
|
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
|
|
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
|
|
Signalling by NGF
|
|
TCR signaling
|
|
Interleukin-1 signaling
|
|
NOD pathwayWP75:Toll-like receptor signaling pathway
|
|
DNA Damage Response (only ATM dependent)
|
|
ErbB Signaling Pathway
|
|
Insulin Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
MAPK Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
Kit receptor signaling pathway
|
|
Transcriptional activation by NRF2
|
|
NLR Proteins
|
|
IL-3 Signaling Pathway
|
|
Cardiac Hypertrophic Response
|
|
Nanoparticle-mediated activation of receptor signaling
|
|
Structural Pathway of Interleukin 1 (IL-1)
|
|
EBV LMP1 signaling
|
|
JAK/STAT
|
|
PDGF Pathway
|
|
Nanoparticle triggered regulated necrosis
|
|
BDNF signaling pathway
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
Corticotropin-releasing hormone
|
|
AGE/RAGE pathway
|
|
TNF alpha Signaling Pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Prostate Cancer
|
|
TSLP Signaling Pathway
|
|
TWEAK Signaling Pathway
|
|
Leptin signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
IL-1 signaling pathway
|
|
Intrinsic Pathway for Apoptosis
|
|
DSCAM interactions
|
|
Apoptosis Modulation and Signaling
|
|
Type II diabetes mellitus
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Physiological and Pathological Hypertrophy of the Heart
|
|
Regulation of toll-like receptor signaling pathway
|
|
Osteoclast SignalingWP706:SIDS Susceptibility Pathways
|
|
Hypothetical Network for Drug Addiction
|
|
Calcium Regulation in the Cardiac Cell
|
|
Endochondral Ossification
|
|
G Protein Signaling Pathways
|
|
Myometrial Relaxation and Contraction Pathways
|
|
Mesodermal Commitment Pathway
|
|
Human Complement System
|
|
DAG and IP3 signaling
|
|
Regulation of Water Balance by Renal Aquaporins
|
|
Dopamine metabolism
|
|
Regulation of Microtubule Cytoskeleton
|
|
FSH signaling pathway
|
|
miRs in Muscle Cell Differentiation
|
|
SREBP signalling
|
|
Opioid Signalling
|
|
Mitotic G2-G2/M phases
|
|
Integration of energy metabolism
|
|
Factors involved in megakaryocyte development and platelet production
|
|
Nicotine Activity on Dopaminergic NeuronsWP673:ErbB Signaling Pathway
|
|
Senescence and Autophagy in Cancer
|
|
Notch Signaling Pathway
|
|
EPO Receptor Signaling
|
|
Pregnane X Receptor pathway
|
|
Aryl Hydrocarbon Receptor Pathway
|
|
Polycystic Kidney Disease Pathway
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Interleukin-11 Signaling Pathway
|
|
Signaling Pathways in Glioblastoma
|
|
Arylhydrocarbon receptor (AhR) signaling pathway
|
|
Integrin-mediated Cell Adhesion
|
|
Angiogenesis
|
|
Androgen receptor signaling pathwayWP61:Notch Signaling Pathway
|
|
Interferon type I signaling pathways
|
|
IL-2 Signaling Pathway
|
|
Inflammatory Response Pathway
|
|
Signaling by SCF-KIT
|
|
DAP12 interactions
|
|
Host Interactions of HIV factors
|
|
PIP3 activates AKT signaling
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Costimulation by the CD28 family
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6028). |
|---|
| REF 2 | Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update. |
|---|
