Drug Information

Drug General Information
Drug ID
D0GZ3A
Former ID
DIB004988
Drug Name
L19-TNF-alpha
Synonyms
Fibromun
Drug Type
Antibody
Indication Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] Phase 2 [548545]
Company
Philogen SpA
Target and Pathway
Target(s) Fibronectin Target Info [550464]
KEGG Pathway PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Amoebiasis
Pathways in cancer
Proteoglycans in cancer
Small cell lung cancer
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Integrin signalling pathway
Pathway Interaction Database Beta1 integrin cell surface interactions
Beta3 integrin cell surface interactions
Angiopoietin receptor Tie2-mediated signaling
Alpha9 beta1 integrin signaling events
Integrins in angiogenesis
Syndecan-4-mediated signaling events
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Syndecan-2-mediated signaling events
VEGFR3 signaling in lymphatic endothelium
Alpha4 beta1 integrin signaling events
Reactome Platelet degranulation
Degradation of the extracellular matrix
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
MAP2K and MAPK activation
WikiPathways Senescence and Autophagy in Cancer
Regulation of Actin Cytoskeleton
Inflammatory Response Pathway
TGF beta Signaling Pathway
Focal Adhesion
miRNA targets in ECM and membrane receptors
Extracellular matrix organization
Nanoparticle-mediated activation of receptor signaling
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
Cell surface interactions at the vascular wall
References
Ref 548545Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026493)
Ref 550464National Cancer Institute Drug Dictionary (drug id 686947).

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