Drug General Information
Drug ID	D0H0FX
Former ID	DND000051
Drug Name	NCX-6560
Synonyms	NCX 6560
Indication	Cardiovascular disorder [ICD10:I00-I99]		Phase 1	[535747]
Company	NicOx
Structure		Download 2D MOL
Target and Pathway
Target(s)	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Target Info	Inhibitor	[535747]
BioCyc Pathway	Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
	Superpathway of cholesterol biosynthesis
	Mevalonate pathway
KEGG Pathway	Terpenoid backbone biosynthesis
	Metabolic pathways
	Biosynthesis of antibiotics
	AMPK signaling pathway
	Bile secretion
NetPath Pathway	IL5 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	TSH Signaling Pathway
PANTHER Pathway	Cholesterol biosynthesis
PathWhiz Pathway	Steroid Biosynthesis
WikiPathways	Statin Pathway
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Activation of Gene Expression by SREBP (SREBF)
	SREBF and miR33 in cholesterol and lipid homeostasis
	Integrated Breast Cancer Pathway
	SREBP signalling
	Cholesterol Biosynthesis
References
Ref 535747	Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2(7):517-26.
Ref 535747	Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2(7):517-26.

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