Drug General Information
Drug ID
D0H1TL
Former ID
DCL000676
Drug Name
ABT-874
Indication Moderate-to-severe plaque psoriasis [ICD9: 696; ICD10:L40] Phase 3 [536651]
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Phase 1 [536651]
Crohn's disease [ICD9: 555; ICD10:K50] Discontinued in Phase 2 [536651]
Company
Abbott; Astra Zeneca
CAS Number
CAS 339308-60-0
Target and Pathway
Target(s) Interleukin-12 ligand Target Info Modulator
KEGG Pathway Cytokine-cytokine receptor interaction
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Jak-STAT signaling pathway
Type I diabetes mellitus
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Measles
Influenza A
Herpes simplex infection
Inflammatory bowel disease (IBD)
Allograft rejection
WikiPathways Toll-like receptor signaling pathway
Aryl Hydrocarbon Receptor Pathway
Allograft Rejection
Regulation of toll-like receptor signaling pathway
References
Ref 536651Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.

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