Drug Information

Drug General Information
Drug ID
D0H2DQ
Former ID
DAP000916
Drug Name
Probucol
Synonyms
Biphenabid; Bisbid; Bisphenabid; Lesterol; Lorelco; Lursell; Lurselle; Panavir; Probucolum; Sinlestal; Superlipid; Almirall Brand of Probucol; Aventis Brand of Probucol; Hoechst Brand of Probucol; DH 581; DH581; DE-3872; DH-581; LORELCO (TN); Probucolum [INN-Latin]; ZERO/001429; Probucol (JAN/USP/INN); Probucol [USAN:BAN:INN:JAN]; Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; Acetone, bis (3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; Acetone, bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; 2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol; 4,4'-(Isopropylidenedithio)bis(2, 6-di-tert-butylphenol); 4,4'-(Isopropylidenedithio)bis(2,6-di-tert-butylphenol); 4,4'-(Isopropylidenedithio)bis[2, 6-di-tert-butylphenol]; 4,4'-(Isopropylidenedithio)bis[2,6-di-tert-butylphenol]; 4,4'-(propane-2,2-diyldisulfanediyl)bis(2,6-di-tert-butylphenol); 4,4'-[(1-Methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]
Drug Type
Small molecular drug
Indication Coronary artery disease [ICD9: 410-414, 429.2; ICD10:I20-I25] Approved [538489], [542297]
Therapeutic Class
Anticholesteremic Agents
Structure
Download
2D MOL

3D MOL
Formula
C31H48O2S2
InChI
InChI=1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3
InChIKey
FYPMFJGVHOHGLL-UHFFFAOYSA-N
CAS Number
CAS 23288-49-5
PubChem Compound ID
4912
PubChem Substance ID
9577, 123183, 505620, 611407, 1916626, 3221724, 5227619, 7734994, 7847542, 7980386, 8139943, 8149708, 8153023, 10321432, 11112687, 11335774, 11361013, 11364190, 11364806, 11366752, 11367368, 11369314, 11369930, 11372495, 11372970, 11373847, 11375530, 11377476, 11378097, 11461985, 11466412, 11467532, 11485156, 11486224, 11489216, 11491253, 11492229, 11495110, 12014197, 14933920, 24899054, 26612166, 26680968, 26748484, 26748485, 29223990, 46508876, 47291113, 47515308, 47662268
SuperDrug ATC ID
C10AX02
SuperDrug CAS ID
cas=023288495
Target and Pathway
Target(s) ATP-binding cassette, sub-family A, member 1 Target Info Modulator [556264]
KEGG Pathway ABC transporters
Fat digestion and absorption
NetPath Pathway Leptin Signaling Pathway
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
Reactome HDL-mediated lipid transport
PPARA activates gene expression
WikiPathways Statin Pathway
Nuclear Receptors in Lipid Metabolism and Toxicity
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Lipid digestion, mobilization, and transport
SREBF and miR33 in cholesterol and lipid homeostasis
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 538489FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017535.
Ref 542297(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7277).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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