Drug Information

Drug General Information
Drug ID
D0H3SL
Former ID
DNC001026
Drug Name
NK3201
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541640]
Structure
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2D MOL

3D MOL
Formula
C31H29N5O6
InChI
InChI=1S/C31H29N5O6/c37-21-34-25-19-33-30(23-12-5-2-6-13-23)36(31(25)41)20-27(39)35-24(18-22-10-3-1-4-11-22)29(40)26(38)14-9-17-42-28-15-7-8-16-32-28/h1-8,10-13,15-16,19,21,24H,9,14,17-18,20H2,(H,34,37)(H,35,39)
InChIKey
QOANBAXBOLUAFA-UHFFFAOYSA-N
CAS Number
CAS 204460-24-2
PubChem Compound ID
213050
PubChem Substance ID
9371116, 12015236, 14837702, 30417287, 49859619, 50947107, 57399660, 103838143, 113453179, 117559970, 129050644, 134339270, 134340288, 135187873, 143196014, 162500210, 172821412, 178103117, 230287846
Target and Pathway
Target(s) Chymase Target Info Inhibitor [535865]
KEGG Pathway Renin-angiotensin system
Reactome Activation of Matrix Metalloproteinases
Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 541640(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6503).
Ref 535865Impact of chymase inhibitor on cardiac function and survival after myocardial infarction. Cardiovasc Res. 2003 Nov 1;60(2):413-20.

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