Drug Information

Drug General Information
Drug ID
D0H4DF
Former ID
DNC010530
Drug Name
GALANTIDE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540536]
Structure
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2D MOL

3D MOL
Formula
C18H19NO
Canonical SMILES
CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl
InChI
1S/C23H30N2O3.ClH/c1-19-10-12-20(13-11-19)28-17-16-25(21-8-4-5-9-22(21)27-2)23(26)18-24-14-6-3-7-15-24;/h4-5,8-13H,3,6-7,14-18H2,1-2H3;1H
InChIKey
SVBMQBOKSANFLA-UHFFFAOYSA-N
PubChem Compound ID
104171
Target and Pathway
Target(s) Galanin receptortype 2 Target Info Inhibitor [530680]
Galanin receptor type 1 Target Info Inhibitor [530680]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 540536(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3896).
Ref 530680J Med Chem. 2010 Feb 25;53(4):1871-5.Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery.

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