Drug General Information
Drug ID	D0H4IU
Former ID	DCL000820
Drug Name	GPI-16072
Drug Type	Small molecular drug
Indication	Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0]		Phase 1	[536447]
Therapeutic Class	Analgesics
Company	MGI Pharma
Structure		Download 2D MOL 3D MOL
Formula	C6H11O7P
Canonical SMILES	C(CC(=O)O)C(CP(O)OO)C(=O)O
InChI	1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(12)13-11/h4,11-12H,1-3H2,(H,7,8)(H,9,10)
InChIKey	HKANXFJUBKMWSW-UHFFFAOYSA-N
PubChem Compound ID	56603712
PubChem Substance ID	134339292
Target and Pathway
Target(s)	Glutamate carboxypeptidase II	Target Info	Inhibitor	[536374]
KEGG Pathway	Alanine, aspartate and glutamate metabolism
	Metabolic pathways
	Vitamin digestion and absorption
NetPath Pathway	TCR Signaling Pathway
	TNFalpha Signaling Pathway
Reactome	Amino acid synthesis and interconversion (transamination)
WikiPathways	One Carbon Metabolism
References
Ref 536447	Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
Ref 536374	Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.

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