Drug General Information
Drug ID	D0H5BC
Former ID	DIB001016
Drug Name	Tosagestin
Synonyms	Org-30659; Org-30659/estradiol
Drug Type	Small molecular drug
Indication	Contraception [ICD10:Z30]		Phase 2	[525775]
Company	Organon BioSciences
Structure		Download 2D MOL 3D MOL
Formula	C21H24O2
Canonical SMILES	[C@]12([C@H]([C@H]3[C@H](C(=C)C1)[C@@H]1C(=CC(=O)CC1)CC<br />3)C=C[C@]2(C#C)O)C
CAS Number	CAS 110072-15-6
PubChem Compound ID	159355
Target and Pathway
Target(s)	Progesterone receptor	Target Info	Agonist	[527744]
KEGG Pathway	Oocyte meiosis
	Progesterone-mediated oocyte maturation
Pathway Interaction Database	Cellular roles of Anthrax toxin
Reactome	Nuclear signaling by ERBB4
	Nuclear Receptor transcription pathway
WikiPathways	Ovarian Infertility Genes
	Signaling by ERBB4
	Nuclear Receptors
References
Ref 525775	Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal women. J Steroid Biochem Mol Biol. 2000 May;73(1-2):39-48.
Ref 527744	Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions. J Steroid Biochem Mol Biol. 1992 Jun;42(5):457-65.

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