Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0H5BC
|
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| Former ID |
DIB001016
|
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| Drug Name |
Tosagestin
|
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| Synonyms |
Org-30659; Org-30659/estradiol
|
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| Drug Type |
Small molecular drug
|
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| Indication | Contraception [ICD10:Z30] | Phase 2 | [1] | ||
| Company |
Organon BioSciences
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C21H24O2
|
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| Canonical SMILES |
[C@]12([C@H]([C@H]3[C@H](C(=C)C1)[C@@H]1C(=CC(=O)CC1)CC<br />3)C=C[C@]2(C#C)O)C
|
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| CAS Number |
CAS 110072-15-6
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Progesterone receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Oocyte meiosis | ||||
| Progesterone-mediated oocyte maturation | |||||
| Pathway Interaction Database | Cellular roles of Anthrax toxin | ||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Nuclear Receptor transcription pathway | |||||
| WikiPathways | Ovarian Infertility Genes | ||||
| Signaling by ERBB4 | |||||
| Nuclear Receptors | |||||
| References | |||||
| REF 1 | Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal women. J Steroid Biochem Mol Biol. 2000 May;73(1-2):39-48. | ||||
| REF 2 | Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions. J Steroid Biochem Mol Biol. 1992 Jun;42(5):457-65. | ||||
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