Drug Information

Drug General Information
Drug ID
D0H5PD
Former ID
DIB013954
Drug Name
CP-0597
Indication Asthma [ICD10:J45] Terminated [546569]
Company
Cortech Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
N1([C@@H](C(=O)N(CC(=O)N[C@H](C(=O)O)CCCNC(=N)N)C2CCCCC<br />2)Cc2c(C1)cccc2)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[<br />C@H]1N(C(=O)[C@H]2N(C(=O)[C@@H](NC(=O)[C@H](N)CCCNC(=N)<br />N)CCCNC(=N)N)CCC2)C[C@@H](C1)O)Cc1sccc1)CO
CAS Number
CAS 172834-07-0
Target and Pathway
Target(s) B2 bradykinin receptor Target Info Antagonist [534432]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Endocrine and other factor-regulated calcium reabsorption
Chagas disease (American trypanosomiasis)
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database Direct p53 effectors
Validated transcriptional targets of deltaNp63 isoforms
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways ACE Inhibitor Pathway
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Nifedipine Activity
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 546569Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008984)
Ref 534432CP-0597, a selective bradykinin B2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusion. Stroke. 1997 Jul;28(7):1430-6.

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