Drug General Information
Drug ID
D0H5WM
Former ID
DIB009921
Drug Name
S-0509
Synonyms
3-[3-[N-(2-Benzoylphenyl)-N-(tert-butoxycarbonylmethyl)carbamoylmethyl]ureido]benzoic acid
Indication Ulcerative colitis [ICD9: 556; ICD10:K51] Phase 2 [521748]
Structure
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2D MOL

3D MOL

CAS Number
CAS 171724-30-4
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info Antagonist [525745], [551871]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 521748ClinicalTrials.gov (NCT00243074) S0509: AZD2171 in Treating Patients With Malignant Pleural Mesothelioma That Cannot Be Removed By Surgery. U.S. National Institutes of Health.
Ref 525745Selective action of a CCK-B/gastrin receptor antagonist, S-0509, on pentagastrin-, peptone meal- and beer-stimulated gastric acid secretion in dogs. Aliment Pharmacol Ther. 2000 Apr;14(4):479-88.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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