Drug Information

Drug General Information
Drug ID
D0H6VZ
Former ID
DIB002168
Drug Name
REV-576
Synonyms
Complement C5a inhibitor (inflammatory disorders/reperfusion injury), Evolutec
Indication Autoimmune diabetes [ICD10:E08-E13] Phase 1 [549591]
Company
Evolutec Group plc
Target and Pathway
Target(s) Complement C5 Target Info Inhibitor [532962]
KEGG Pathway Complement and coagulation cascades
Prion diseases
Pertussis
Staphylococcus aureus infection
Herpes simplex infection
Systemic lupus erythematosus
Reactome Activation of C3 and C5
Peptide ligand-binding receptors
G alpha (i) signalling events
Regulation of Complement cascade
WikiPathways Complement Activation, Classical Pathway
Human Complement System
Spinal Cord Injury
Allograft Rejection
GPCR ligand binding
GPCR downstream signaling
Complement cascade
References
Ref 549591Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800042907)
Ref 532962Complement C5-inhibitor rEV576 (coversin) ameliorates in-vivo effects of antiphospholipid antibodies. Lupus. 2014 Oct;23(12):1324-6.

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