Drug Information

Drug General Information
Drug ID
D0H7GQ
Former ID
DCL000899
Drug Name
NS 1209
Drug Type
Small molecular drug
Indication Epilepsy; Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G40, G64, G90.0] Phase 2 [530030], [536498]
Therapeutic Class
Analgesics
Company
NeuroSearch
Structure
Download
2D MOL

3D MOL
Formula
C24H28N4O7S
Canonical SMILES
CN1CCC2=C(C1)C3=NC(=O)C(=C3C=C2C4=CC=C(C=C4)S(=O)(=O)N(<br />C)C)NOC(CCO)C(=O)O
InChI
1S/C24H28N4O7S/c1-27(2)36(33,34)15-6-4-14(5-7-15)17-12-18-21(19-13-28(3)10-8-16(17)19)25-23(30)22(18)26-35-20(9-11-29)24(31)32/h4-7,12,20,29H,8-11,13H2,1-3H3,(H,31,32)(H,25,26,30)
InChIKey
CFJRSKULEDUDKL-UHFFFAOYSA-N
CAS Number
CAS 205645-02-9
PubChem Compound ID
6918411
PubChem Substance ID
12015215, 14762706, 14884972, 43529781, 57371918, 77880708, 103500389, 104077535, 104231700, 114787928, 134339351, 135260950, 136352525, 138035799, 139274446, 223701029, 230325145, 241381508, 246195774, 252063038
Target and Pathway
Target(s) Glutamate receptor, ionotropic kainate 1 Target Info Modulator [530030]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 530030The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study. Anesth Analg. 2009 Apr;108(4):1311-9.
Ref 536498Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22.
Ref 530030The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study. Anesth Analg. 2009 Apr;108(4):1311-9.

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