Drug General Information
Drug ID	D0H8EO
Former ID	DNC010136
Drug Name	3,3-diethyl-1-phenylazetidine-2,4-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530511]
Structure		Download 2D MOL 3D MOL
Formula	C13H15NO2
Canonical SMILES	CCC1(C(=O)N(C1=O)C2=CC=CC=C2)CC
InChI	1S/C13H15NO2/c1-3-13(4-2)11(15)14(12(13)16)10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3
InChIKey	KDXSTYUPRNLDGW-UHFFFAOYSA-N
PubChem Compound ID	139973
Target and Pathway
Target(s)	Leukocyte elastase	Target Info	Inhibitor	[530511]
KEGG Pathway	Transcriptional misregulation in cancer
	Systemic lupus erythematosus
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	C-MYB transcription factor network
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Human Complement System
	Degradation of collagen
References
Ref 530511	J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.
Ref 530511	J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

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