Drug Information

Drug General Information
Drug ID
D0H8QQ
Former ID
DIB018378
Drug Name
[3H]PGD2
Synonyms
[3H]11-dehydroprostaglandin F2-alpha; [3H]prostaglandin D2; [3H]-PGD2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539191]
Structure
Download
2D MOL
Formula
C20H32O5
InChI
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1
InChIKey
BHMBVRSPMRCCGG-OUTUXVNYSA-N
PubChem Compound ID
448457
PubChem Substance ID
3964, 583767, 4265955, 7889816, 7980420, 8143213, 10300216, 12012669, 15496745, 24898605, 26754808, 26754809, 36890302, 46504574, 47515086, 48258962, 49700655, 50026788, 50110785, 53788536, 57404870, 77723738, 92297650, 92309902, 99300816, 99302334, 104046434, 104639469, 123099371, 126524027, 127277724, 127277725, 127277726, 127277727, 127277728, 127277729, 127277730, 127277731, 127277732, 127277733, 127346781, 127346782, 127346783, 135001740, 135651538, 135651568, 137005673, 142697392, 143486570, 160965276
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Agonist [527971]
Prostaglandin D2 receptor Target Info Agonist [528126]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Small Ligand GPCRs
GPCR downstream signaling
References
Ref 539191(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1891).
Ref 527971On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2. Mol Pharmacol. 2006 Apr;69(4):1441-53. Epub 2006 Jan 17.
Ref 528126GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. Br J Pharmacol. 2006 Jun;148(3):326-39.

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