Drug Information

Drug General Information
Drug ID
D0H8VY
Former ID
DCL000072
Drug Name
BMS-201038
Synonyms
AEGR 733; AEGR733; BMS 201038; BMS 201238; BMS201038; AEGR-733; BMS 201038-01
Drug Type
Small molecular drug
Indication Familial hypercholesterolemia [ICD9: 272; ICD10:E78.0] Approved [532210], [542462]
Company
Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL
Formula
C39H37F6N3O2
InChI
InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
InChIKey
MBBCVAKAJPKAKM-UHFFFAOYSA-N
CAS Number
CAS 202833-31-6
PubChem Compound ID
9853053
PubChem Substance ID
14815135, 24148206, 45275369, 77003727, 103426685, 103995395, 124490377, 126681450, 128569932, 135194833, 137125822, 142063799, 160962914, 162224728, 172918127, 175266823, 175427108, 178104011, 189294433, 198991931, 223218466, 223662329, 226644605, 251970555, 252450349, 252558102, 252672097, 252822638
Target and Pathway
Target(s) Microsomal triglyceride transfer protein, large subunit Target Info Inhibitor [536426], [537143]
KEGG Pathway Fat digestion and absorption
Reactome Chylomicron-mediated lipid transport
WikiPathways Statin Pathway
Lipid digestion, mobilization, and transport
References
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 542462(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7439).
Ref 536426Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Apr;29(3):231-45.
Ref 537143Dyslipidemia and cardiovascular diseases. Curr Opin Lipidol. 2009 Apr;20(2):157-8.

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