TTD | Drug: D0H9AX

Drug General Information
Drug ID	D0H9AX
Former ID	DIB020168
Drug Name	L-736380
Synonyms	L 736380; L736380
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[543271]
Structure		Download 2D MOL
Formula	C25H29N9O2
InChI	InChI=1S/C25H29N9O2/c1-33(24-29-31-32-30-24)18-12-8-11-17(15-18)26-25(36)28-22-23(35)34(2)20-14-7-6-13-19(20)21(27-22)16-9-4-3-5-10-16/h6-8,11-16,22H,3-5,9-10H2,1-2H3,(H2,26,28,36)(H,29,30,31,32)/t22-/m0/s1
InChIKey	MYPNMQPMQUAOTH-QFIPXVFZSA-N
PubChem Compound ID	9935175
PubChem Substance ID	14908264, 15554985, 80441656, 135650485, 160676092, 225146249, 234698292
Target and Pathway
Target(s)	Cholecystokinin receptor type A	Target Info	Antagonist	[534125]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Insulin secretion
	Pancreatic secretion
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543271	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 880).
Ref 534125	Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas. J Med Chem. 1996 Feb 16;39(4):842-9.

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Drug Information