Drug Information

Drug General Information
Drug ID
D0HS5P
Former ID
DIB019058
Drug Name
calindol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542201]
Structure
Download
2D MOL
Formula
C21H20N2
InChI
InChI=1S/C21H20N2/c1-15(19-11-6-9-16-7-2-4-10-20(16)19)22-14-18-13-17-8-3-5-12-21(17)23-18/h2-13,15,22-23H,14H2,1H3/t15-/m1/s1
InChIKey
JLPWXRZETODYFC-OAHLLOKOSA-N
PubChem Compound ID
9882793
PubChem Substance ID
14849556, 14949407, 24170082, 45629743, 77290027, 134459541, 135650049, 139244560, 140324928, 163353295, 174006301, 230062531, 248476750
Target and Pathway
Target(s) Extracellular calcium-sensing receptor Target Info Modulator (allosteric modulator) [527083]
GPRC6 receptor Target Info Modulator (allosteric modulator) [530456]
Pathway Interaction Database E-cadherin signaling in keratinocytes
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 542201(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 719).
Ref 527083N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor.Bioorg Med Chem Lett. 2004 Jun 21;14(12):3345-9.
Ref 530456Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor. Cell Calcium. 2009 Nov-Dec;46(5-6):323-32.

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