Drug Information

Drug General Information
Drug ID
D0HS5V
Former ID
DNCL002613
Drug Name
Brivanib
Drug Type
Small molecular drug
Indication Breast cancer; Liver cancer [ICD9: 174, 175, 140-229, 155, 203.0; ICD10:C50, C22] Phase 3 [523016], [541015]
Company
Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL
Formula
C19H19FN4O3
InChI
InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1
InChIKey
WCWUXEGQKLTGDX-LLVKDONJSA-N
PubChem Compound ID
11234052
PubChem Substance ID
16317953, 23414456, 42313638, 77365611, 92721417, 99436978, 103483726, 104069124, 124490329, 124756986, 125163791, 126619161, 126661321, 126661731, 126730839, 131480673, 134343564, 134964399, 135252957, 135727386, 136367284, 136368025, 136377882, 136920387, 137276004, 141643704, 144115752, 152059805, 152088878, 152258181, 152344141, 160647017, 162011436, 162029696, 162110616, 162200058, 164041879, 164775472, 170500439, 174475086, 174539891, 177748734, 178102299, 180404088, 184816398, 188899522, 198948130, 223573483, 223677759, 223705289
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 2 Target Info Modulator [1572591]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Proteoglycans in cancer
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
VEGF and VEGFR signaling network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY network
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
WikiPathways Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Signaling by VEGF
Angiogenesis
References
Ref 523016ClinicalTrials.gov (NCT01108705) Comparison of Brivanib and Best Supportive Care (BSC) With Placebo and BSC for Treatment of Liver Cancer in Asian Patients Who Have Failed Sorafenib Treatment. U.S. National Institutes of Health.
Ref 541015(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5671).
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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