Drug Information

Drug General Information
Drug ID
D0I0RJ
Former ID
DAP000187
Drug Name
Amiloride
Synonyms
Amiclaran; Amilorida; Amiloridum; Amipramidin; Amipramizid; Amipramizide; Amiprazidine; Amyloride; Guanamprazin; Guanamprazine; Midamor; Amiloride HCL; Amiloride hydrochloride hydrate; Amiclaran (TN); Amikal (Hydrochloride dihydrate); Amilorida [INN-Spanish]; Amiloride (INN); Amiloride [INN:BAN]; Amiloridum [INN-Latin]; Biduret (TN); Midamor (Hydrochloride dihydrate); MK-870 (Hydrochloride dihydrate); AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8)); N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide; N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride; 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide; 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide; Amiloride (Na-Ca chanel blocker)
Drug Type
Small molecular drug
Indication Congestive heart failure; Hypertension [ICD9: 428; ICD10:I50] Approved [538224], [539551]
Therapeutic Class
Diuretics
Company
Tornett pharmaceutical
Structure
Download
2D MOL

3D MOL
Formula
C6H8ClN7O
InChI
InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
InChIKey
XSDQTOBWRPYKKA-UHFFFAOYSA-N
CAS Number
CAS 2016-88-8
PubChem Compound ID
16231
PubChem Substance ID
9039, 621650, 838821, 3182570, 5866713, 7885870, 8162159, 11110775, 11113372, 11120240, 11120728, 11121216, 11121637, 11122117, 11335357, 11360596, 11362706, 11362808, 11365268, 11365370, 11367830, 11367932, 11370683, 11370684, 11371426, 11373431, 11373683, 11375992, 11376094, 11461568, 11466035, 11467155, 11483872, 11485670, 11487934, 11490109, 11491947, 11493848, 14798141, 26751628, 26751629, 29284103, 46391861, 46508156, 46516430, 47217018, 47217019, 47291344, 47440507, 47440508
ChEBI ID
ChEBI:2639
SuperDrug ATC ID
C03DB01
SuperDrug CAS ID
cas=002609463
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Acid-sensing ion channel ASIC1a/ASIC1b Target Info Modulator [556264]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome Stimuli-sensing channels
WikiPathways Iron uptake and transport
References
Ref 538224FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 070346.
Ref 539551(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2421).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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