Drug General Information
Drug ID	D0I0VK
Former ID	DNC000660
Drug Name	FR149175
Drug Type	Small molecular drug
Indication	Type 2 diabetes [ICD9: 250; ICD10:E11]		Terminated	[546562]
Structure		Download 2D MOL 3D MOL
Formula	C11H22O2
Canonical SMILES	CCCCCCC(CCC)C(=O)O
InChI	1S/C11H22O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h10H,3-9H2,1-2H3,(H,12,13)/t10-/m1/s1
InChIKey	YCYMCMYLORLIJX-SNVBAGLBSA-N
CAS Number	CAS 185517-21-9
PubChem Compound ID	208925
PubChem Substance ID	9368737, 12015175, 15171440, 15195263, 30413566, 47207953, 57399566, 78156578, 103066752, 103079595, 113442118, 117541332, 124894576, 129777841, 132572103, 134339356, 134340030, 135183048, 135694756, 137061534, 142551269, 144206875, 162254961, 162807354, 163413958, 163884615, 164835957, 172859255, 175426981, 180371084, 198967322, 223545538, 224174346, 226396378, 242590696, 252158144, 252513052
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Agonist	[538035]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546562	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008959)
Ref 538035	FR149175, a beta 3-adrenoceptor-selective agonist, is a possible therapeutic agent for non-insulin-dependent diabetes mellitus. Jpn J Pharmacol. 1997 May;74(1):109-12.

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