Drug Information

Drug General Information
Drug ID
D0I0ZO
Former ID
DIB015781
Drug Name
Anti-CD45 mabs
Synonyms
AHCD45 therapy, Baylor College; YTH-24; YTH-24/54; YTH-25.4; YTH-54.12; Anti-CD45 mAbs (stem cell transplantation/cancer); Anti-CD45 mAbs (stem cell transplantation/cancer), Baylor College
Drug Type
Antibody
Indication Lymphoma [ICD9: 202.8, 208.9; ICD10:C81-C86] Phase 1 [521588]
Company
Baylor College of Medicine
Target and Pathway
Target(s) Leukocyte common antigen Target Info [528286]
KEGG Pathway Cell adhesion molecules (CAMs)
T cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
Primary immunodeficiency
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway B cell activation
JAK/STAT signaling pathway
T cell activation
Pathway Interaction Database BCR signaling pathway
TCR signaling in na&#xef
TCR signaling in na&#xef
CXCR4-mediated signaling events
Reactome Phosphorylation of CD3 and TCR zeta chains
Other semaphorin interactions
WikiPathways Interferon type I signaling pathways
EPO Receptor Signaling
B Cell Receptor Signaling Pathway
TCR signaling
Semaphorin interactions
References
Ref 521588ClinicalTrials.gov (NCT00078546) EBV-Specific CTLs Following CD45 Antibody to Patients With Epstein-Barr Virus (EBV) + Nasopharyngeal Carcinoma (NPC). U.S. National Institutes of Health.
Ref 528286CD45 monoclonal antibody-mediated cytolysis of human NK and T lymphoma cells. Haematologica. 2006 Jul;91(7):886-94.

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