Drug Information

Drug General Information
Drug ID
D0I1GV
Former ID
DIB018502
Drug Name
1-arylmethylpyrrolidin-2-yl ethanol amine
Synonyms
compound 26a [PMID: 16216508]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527795]
Structure
Download
2D MOL
Formula
C26H31N3OS
InChI
InChI=1S/C26H31N3OS/c1-26(2,15-22-14-21-9-3-4-11-25(21)31-22)28-17-24(30)23-10-6-12-29(23)18-20-8-5-7-19(13-20)16-27/h3-5,7-9,11,13-14,23-24,28,30H,6,10,12,15,17-18H2,1-2H3/t23-,24-/m1/s1
InChIKey
HCLQARMRCPEALF-DNQXCXABSA-N
PubChem Compound ID
44405854
PubChem Substance ID
103474835, 104061056, 135649657
Target and Pathway
Target(s) Extracellular calcium-sensing receptor Target Info Antagonist [527795]
Pathway Interaction Database E-cadherin signaling in keratinocytes
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 527795Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5478-82. Epub 2005 Oct 10.
Ref 527795Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5478-82. Epub 2005 Oct 10.

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