Drug General Information
Drug ID	D0I1OS
Former ID	DIB009977
Drug Name	E-2212
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Phase 1	[523211]
Company	Eisai Co Ltd
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Gamma-secretase	Target Info	Modulator	[532323]
KEGG Pathway	Notch signaling pathway
	Alzheimer's disease
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Alzheimer disease-presenilin pathway
	Notch signaling pathway
Pathway Interaction Database	Notch signaling pathway
	Presenilin action in Notch and Wnt signaling
	p75(NTR)-mediated signaling
	Syndecan-3-mediated signaling events
Reactome	Nuclear signaling by ERBB4
	Regulated proteolysis of p75NTR
	NRIF signals cell death from the nucleus
	Activated NOTCH1 Transmits Signal to the Nucleus
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	NOTCH2 Activation and Transmission of Signal to the Nucleus
	EPH-ephrin mediated repulsion of cells
WikiPathways	Notch Signaling Pathway
	Signaling by ERBB4
	Signaling by NOTCH3
	Signaling by NOTCH4
	Signaling by NOTCH1
	Signaling by NOTCH2
	Notch Signaling Pathway
	Signalling by NGF
References
Ref 523211	ClinicalTrials.gov (NCT01221259) A Randomized, Double-blind, Placebo-controlled, Sequential Ascending, Single-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2212 in Healthy Subjects. U.S. National Institutes of Health.
Ref 532323	Development and mechanism of gamma-secretase modulators for Alzheimer's disease. Biochemistry. 2013 May 14;52(19):3197-216.

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