Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0I1ZY
|
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| Former ID |
DIB006474
|
||||
| Drug Name |
Tralokinumab
|
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| Synonyms |
CAT-354; Anti-IL 13 monoclonal antibody, CAT/AstraZeneca; IL-13 antagonist, CAT/AstraZeneca; Interleukin-13 antagonist, CAT/AstraZeneca
|
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| Drug Type |
Monoclonal antibody
|
||||
| Company |
Ception Therapeutics
|
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| Target and Pathway | |||||
| Target(s) | Interleukin-13 receptor alpha-2 chain | Target Info | Modulator | ||
| KEGG Pathway | Jak-STAT signaling pathway | ||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PANTHER Pathway | Interleukin signaling pathway | ||||
| Pathway Interaction Database | IL4-mediated signaling events | ||||
| References | |||||
| Ref 524980 | ClinicalTrials.gov (NCT02281357) Phase 3 Study to Evaluate the Efficacy & Safety of Tralokinumab in Adults & Adolescents With Oral Corticosteroid Dependent Asthma. U.S. National Institutes of Health. | ||||
| Ref 542917 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8001). | ||||
| Ref 889368 | ClinicalTrials.gov (NCT01402986) A Safety and Efficacy Study of Tralokinumab in Adults With Asthma | ||||
| Ref 889371 | ClinicalTrials.gov (NCT01482884) Evaluation of Efficacy and Safety of Tralokinumab in Patients With Active, Moderate-to-severe Ulcerative Colitis | ||||
| Ref 889374 | ClinicalTrials.gov (NCT01592396) A Phase 1, Open-label Study to Investigate the Pharmacokinetics of Tralokinumab (CAT-354) in Adolescents With Asthma | ||||
| Ref 889376 | ClinicalTrials.gov (NCT01629667) A Phase 2, Randomized Dose-ranging Study to Evaluate the Efficacy of Tralokinumab in Adults With Idiopathic Pulmonary Fibrosis | ||||
| Ref 889391 | ClinicalTrials.gov (NCT02085473) A Phase 1 Study to Evaluate the Pharmacokinetics and Tolerability of Tralokinumab When Delivered at Different Flow Rates to Healthy Volunteers | ||||
| Ref 889408 | ClinicalTrials.gov (NCT02347176) Phase 2 Study to Evaluate the Efficacy and Safety of Tralokinumab in Adults With Atopic Dermatitis | ||||
| Ref 889414 | ClinicalTrials.gov (NCT02449473) Study to Evaluate Efficacy & Safety of Tralokinumab in Subjects With Asthma Inadequately Controlled on Corticosteroids | ||||
| Ref 889420 | ClinicalTrials.gov (NCT02684097) A Pilot Study of Tralokinumab in Subjects With Moderate to Severe Alopecia Areata | ||||
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