Drug Information

Drug General Information
Drug ID
D0I2FC
Former ID
DNC010486
Drug Name
Burnamine-17-O-3',4',5'-trimethoxybenzoate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530756]
Structure
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2D MOL

3D MOL
Formula
C31H34N2O8
Canonical SMILES
CC=C1CN2C3CC1C(C45C3(NC6=CC=CC=C64)OC2C5)(COC(=O)C7=CC(<br />=C(C(=C7)OC)OC)OC)C(=O)OC
InChI
1S/C31H34N2O8/c1-6-17-15-33-24-13-20(17)29(28(35)39-5,16-40-27(34)18-11-22(36-2)26(38-4)23(12-18)37-3)30-14-25(33)41-31(24,30)32-21-10-8-7-9-19(21)30/h6-12,20,24-25,32H,13-16H2,1-5H3/b17-6+/t20-,24-,25-,29-,30-,31-/m0/s1
InChIKey
CLCDMQIWPVOTMQ-RKJOYVLNSA-N
PubChem Compound ID
15837283
Target and Pathway
Target(s) Sodium/glucose cotransporter 1 Target Info Inhibitor [530756]
mRNA of sodium-glucosetransporter-2 Target Info Inhibitor [530756]
KEGG Pathway Carbohydrate digestion and absorption
Bile secretion
Mineral absorption
PathWhiz Pathway Lactose Degradation
Trehalose Degradation
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transportersR-HSA-189200:Hexose transport
Inositol transporters
WikiPathways NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Metabolism of carbohydratesWP2884:NRF2 pathway
References
Ref 530756Bioorg Med Chem. 2010 Mar 15;18(6):2152-8. Epub 2010 Feb 6.Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.
Ref 530756Bioorg Med Chem. 2010 Mar 15;18(6):2152-8. Epub 2010 Feb 6.Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.

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