Drug Information
Drug General Information | |||||
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Drug ID |
D0I2RB
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Former ID |
DIB001081
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Drug Name |
ONO-4641
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Synonyms |
Sphingosine-1-phosphate agonist (tablet, mutiple sclerosis), Ono
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Indication | Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] | Phase 2 | [523225] | ||
Company |
Emd serono
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Structure |
Download2D MOL |
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Canonical SMILES |
c1(ccc(cc1)/C(=C/CNCCC(=O)O)/C)OCCCc1ccccc1
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Target and Pathway | |||||
Target(s) | Sphingosine 1-phosphate receptor 1 | Target Info | Agonist | [532134], [532456] | |
References | |||||
Ref 532134 | Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis. Clin Exp Immunol. 2013 Jan;171(1):54-62. | ||||
Ref 532456 | Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702. |
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