Drug Information

Drug General Information
Drug ID
D0I5CS
Former ID
DIB020657
Drug Name
PD 176252
Synonyms
PD-176252
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541417]
Structure
Download
2D MOL
Formula
C32H36N6O5
InChI
InChI=1S/C32H36N6O5/c1-31(18-22-19-33-27-9-5-4-8-26(22)27,37-30(40)36-23-10-12-24(13-11-23)38(41)42)29(39)35-21-32(16-6-3-7-17-32)28-15-14-25(43-2)20-34-28/h4-5,8-15,19-20,33H,3,6-7,16-18,21H2,1-2H3,(H,35,39)(H2,36,37,40)/t31-/m0/s1
InChIKey
NNFUWNLENRUDHR-HKBQPEDESA-N
PubChem Compound ID
9829828
PubChem Substance ID
14789002, 14813445, 24131211, 44927950, 75306989, 99030138, 103294493, 103965449, 128726699, 135650804, 135698675, 137216386, 163123841, 198961060, 204362258, 223369855, 226726687, 241376022, 251962206, 252156644
Target and Pathway
Target(s) Bombesin receptor Target Info Antagonist [530159]
Gastrin-releasing peptide receptor Target Info Antagonist [534800]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRsWP455:GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCRs, Other
References
Ref 541417(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 626).
Ref 530159Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors. Peptides. 2009 Aug;30(8):1473-86.
Ref 534800PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2589-94.

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