TTD | Drug: D0I5UU

Drug General Information
Drug ID	D0I5UU
Former ID	DNC001035
Drug Name	Norastemizole
Drug Type	Small molecular drug
Indication	Discovery agent		Discontinued in Preregistration	[546280]
Structure		Download 2D MOL 3D MOL
Formula	C19H21FN4
Canonical SMILES	C1CNCCC1NC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F
InChI	1S/C19H21FN4/c20-15-7-5-14(6-8-15)13-24-18-4-2-1-3-17(18)23-19(24)22-16-9-11-21-12-10-16/h1-8,16,21H,9-13H2,(H,22,23)
InChIKey	SFOVDSLXFUGAIV-UHFFFAOYSA-N
CAS Number	CAS 75970-64-8
PubChem Compound ID	123618
PubChem Substance ID	10240800, 11538012, 12014873, 14777201, 29303850, 47207679, 50066133, 57340487, 76897838, 96099860, 103088876, 103157266, 103247597, 104011330, 104418924, 109614770, 117509932, 129228977, 134339274, 134340293, 135079335, 137237678, 140278629, 164231482, 179151099, 198989887, 224821565, 226408231, 241135945
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Modulator
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
Reactome	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546280	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007228)

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Drug Information