Drug Information

Drug General Information
Drug ID
D0I6HV
Former ID
DIB020552
Drug Name
NNC 92-1687
Synonyms
NNC92-1687
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540452]
Structure
Download
2D MOL
Formula
C15H12N2O3S
InChI
InChI=1S/C15H12N2O3S/c18-12-6-5-9(7-13(12)19)14(20)8-21-15-16-10-3-1-2-4-11(10)17-15/h1-7,18-19H,8H2,(H,16,17)
InChIKey
NVYSVDRYESXWBD-UHFFFAOYSA-N
PubChem Compound ID
4206177
PubChem Substance ID
6165470, 7979917, 8385667, 14849537, 35491797, 51963667, 53801051, 56373703, 58107264, 89665901, 95534976, 103393157, 103962828, 112756905, 137018858, 143823525, 145260443, 166678541, 228739669
Target and Pathway
Target(s) Glucagon receptor Target Info Antagonist [534773]
KEGG Pathway Neuroactive ligand-receptor interaction
Glucagon signaling pathway
Reactome Glucagon signaling in metabolic regulation
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 540452(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3515).
Ref 534773Discovery and structure-activity relationship of the first non-peptide competitive human glucagon receptor antagonists. J Med Chem. 1998 Dec 17;41(26):5150-7.

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