Drug General Information
Drug ID	D0I6ZO
Former ID	DIB013334
Drug Name	AZD-5213
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Phase 2	[523825]
Company	AstraZeneca plc
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Histamine H3 receptor	Target Info	Antagonist	[531888]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 523825	ClinicalTrials.gov (NCT01548287) A Study of the Safety and Tolerability of AZD5213 Effect on Sleep for Patients With Alzheimer's/Cognitive Impairment. U.S. National Institutes of Health.
Ref 531888	SAR110894, a potent histamine H??receptor antagonist, displays procognitive effects in rodents. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14.

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