Drug General Information
Drug ID	D0I9QH
Former ID	DIB000179
Drug Name	SR-58878
Indication	Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1]		Terminated	[549821]
Company	Sanofi-Synthelabo
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12c(ccc(c1)OCC(=O)O)CC[C@@H](C2)NC[C@H](c1cc(Cl)ccc1)O
CAS Number	CAS 191533-25-2
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Modulator	[543754]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 549821	Clinical pipeline report, company report or official report of Sanofi-Synthelabo.
Ref 543754	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 30).

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